User:Mr. Ibrahem/Paricalcitol

Mr. Ibrahem/Paricalcitol
Clinical data
Trade names	Zemplar
Other names	19-nor-1,25-(OH)2-vitamin D2
AHFS/Drugs.com	Monograph
MedlinePlus	a682335
Pregnancy; category	AU: C; ;
Routes of; administration	By mouth, intravenous
Drug class	Vitamin D
Legal status
Legal status	AU: S4 (Prescription only); CA: ℞-only; UK: POM (Prescription only); US: ℞-only;
Pharmacokinetic data
Bioavailability	72%
Protein binding	99.8%
Metabolism	Hepatic
Elimination half-life	14-20 hours
Excretion	Faeces (74%), urine (16%)
Identifiers
	IUPAC name (1R,3R,7E,17β)-17-[(1R,2E,4S)-5-hydroxy-1,4,5-trimethylhex-2-en-1-yl]-9,10-secoestra-5,7-diene-1,3-diol;
Chemical and physical data
Formula	C27H44O3
Molar mass	416.646 g·mol−1
	InChI InChI=1S/C27H44O3/c1-18(8-9-19(2)26(3,4)30)24-12-13-25-21(7-6-14-27(24,25)5)11-10-20-15-22(28)17-23(29)16-20/h8-11,18-19,22-25,28-30H,6-7,12-17H2,1-5H3/b9-8+,21-11+/t18-,19+,22-,23-,24-,25+,27-/m1/s1 ; Key:BPKAHTKRCLCHEA-UBFJEZKGSA-N ;
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Paricalcitol, sold under the trade name Zemplar, is a medication used to prevent and treat hyperparathyroidism due to chronic kidney disease.^[3] It is taken by mouth.^[3]

Common side effects include diarrhea, allergic reactions, nausea, headache, and trouble sleeping.^[1] Other side effects may include high calcium and aluminum toxicity.^[1] There are concerns with use in pregancy.^[3] It is a form of calcitriol, an active type of vitamin D.^[1]

Paricalcitol was patented in 1989 and approved for medical use in 1998.^[4] It is available as a generic medication.^[1] In the United Kingdom 28 doses of 1 microgram costs the NHS about £70 as of 2021.^[3] This amount in the United States is about 100 USD.^[5]

References[edit]

^ ^a ^b ^c ^d ^e ^f "Paricalcitol Monograph for Professionals". Drugs.com. Archived from the original on 27 February 2021. Retrieved 26 October 2021.
^ ^a ^b ^c ^d ^e "Zemplar (paricalcitol) dosing, indications, interactions, adverse effects, and more". Medscape Reference. WebMD. Archived from the original on 2 February 2014. Retrieved 26 January 2014.
^ ^a ^b ^c ^d ^e BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 1137. ISBN 978-0857114105.
^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 452. ISBN 9783527607495. Archived from the original on 2021-01-22. Retrieved 2021-03-18.
^ "Paricalcitol Prices, Coupons & Patient Assistance Programs". Drugs.com. Archived from the original on 10 August 2020. Retrieved 26 October 2021.

[AHFS2021-1] ^ ^a ^b ^c ^d ^e ^f "Paricalcitol Monograph for Professionals". Drugs.com. Archived from the original on 27 February 2021. Retrieved 26 October 2021.

[MSR-2] "Zemplar (paricalcitol) dosing, indications, interactions, adverse effects, and more". Medscape Reference. WebMD. Archived from the original on 2 February 2014. Retrieved 26 January 2014.

[BNF81-3] BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 1137. ISBN 978-0857114105.

[4] Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 452. ISBN 9783527607495. Archived from the original on 2021-01-22. Retrieved 2021-03-18.

[5] "Paricalcitol Prices, Coupons & Patient Assistance Programs". Drugs.com. Archived from the original on 10 August 2020. Retrieved 26 October 2021.

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