User:Mr. Ibrahem/Oxazepam

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Mr. Ibrahem/Oxazepam
Clinical data
Trade namesSerax, Alepam, others
AHFS/Drugs.comMonograph
Routes of
administration		By mouth
Drug classBenzodiazepine[1]
Legal status
Legal status
Pharmacokinetic data
Bioavailability92.8%
MetabolismLiver (glucuronidation)
Elimination half-life6–9 h[2][3][4]
ExcretionKidney
Identifiers
  • 7-Chloro-3-hydroxy-5-phenyl-1,3-dihydro-1,4-benzodiazepin-2-one[5]
Chemical and physical data
FormulaC15H11ClN2O2
Molar mass286.71 g·mol−1
3D model (JSmol)
Melting point205 to 206 °C (401 to 403 °F)
  • OC1N=C(C2=C(NC1=O)C=CC(Cl)=C2)C3=CC=CC=C3
  • InChI=1S/C15H11ClN2O2/c16-10-6-7-12-11(8-10)13(9-4-2-1-3-5-9)18-15(20)14(19)17-12/h1-8,15,18,20H ☒N
  • Key:IMAUTQQURLXUGJ-UHFFFAOYSA-N ☒N
  (verify)

Oxazepam is a benzodiazepine used to treat anxiety, trouble sleeping, and alcohol withdrawal.[6][1] It is taken by mouth.[1] It has a relatively slow onset and prolonged effects.[7]

Common side effects include sleepiness, dizziness, and headache.[1] Other side effects may include abuse, agitation, memory loss, suicide, and slurred speech.[6] Use is not recommended during early pregnancy.[1] Use is not generally recommended with opioids.[1] It is believed to work via the GABA neurotransmitter.[1]

Oxazepam was patented in 1962 and approved for medical use in 1964.[8] It is available as a generic medication.[6] In the United Kingdom 28 tablets of 15 mg costs the NHS about £6 as of 2021.[6] In the United States this amount costs about 30 USD.[9]

References[edit]

  1. ^ a b c d e f g h i j "Oxazepam Monograph for Professionals". Drugs.com. Archived from the original on 10 February 2018. Retrieved 10 November 2021.
  2. ^ "Encadré 1. Anxiolytiques à demi-vie courte (< 20 heures) et sans métabolite actif par ordre alphabétique de DCI" (PDF). Archived (PDF) from the original on 2021-06-28. Retrieved 2021-09-06.
  3. ^ Sonne, J; Loft, S; Døssing, M; Vollmer-Larsen, A; Olesen, KL; Victor, M; Andreasen, F; Andreasen, PB (1988). "Bioavailability and pharmacokinetics of oxazepam". European Journal of Clinical Pharmacology. 35 (4): 385–9. doi:10.1007/bf00561369. PMID 3197746. S2CID 31007311.
  4. ^ Sonne, J; Boesgaard, S; Poulsen, H E; Loft, S; Hansen, J M; Døssing, M; Andreasen, F (November 1990). "Pharmacokinetics and pharmacodynamics of oxazepam and metabolism of paracetamol in severe hypothyroidism". British Journal of Clinical Pharmacology. 30 (5): 737–742. doi:10.1111/j.1365-2125.1990.tb03844.x. PMC 1368175. PMID 2271373.
  5. ^ CID 4616 from PubChem
  6. ^ a b c d e f BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. X. ISBN 978-0857114105.
  7. ^ Fitzgerald, Margaret A. (14 March 2017). Nurse Practitioner Certification Examination and Practice Preparation. F.A. Davis. p. 346. ISBN 978-0-8036-6917-8. Archived from the original on 10 November 2021. Retrieved 10 November 2021.
  8. ^ Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 536. ISBN 9783527607495. Archived from the original on 2021-08-28. Retrieved 2021-09-06.
  9. ^ "Oxazepam Prices, Coupons & Patient Assistance Programs". Drugs.com. Archived from the original on 23 April 2021. Retrieved 10 November 2021.
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