User:Mr. Ibrahem/Nateglinide

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Mr. Ibrahem/Nateglinide
Clinical data
Trade namesStarlix
AHFS/Drugs.comMonograph
MedlinePlusa699057
License data
Routes of
administration
By mouth
Drug classMeglitinide[1]
Legal status
Legal status
Pharmacokinetic data
Protein binding98%
Elimination half-life1.5 hours
Identifiers
  • (2R)-2-({[trans-4-(1-methylethyl)cyclohexyl]carbonyl}amino)-3-phenylpropanoic acid
Chemical and physical data
FormulaC19H27NO3
Molar mass317.429 g·mol−1
3D model (JSmol)
  • O=C(N[C@H](Cc1ccccc1)C(O)=O)[C@H]2CC[C@@H](CC2)C(C)C
  • InChI=1S/C19H27NO3/c1-13(2)15-8-10-16(11-9-15)18(21)20-17(19(22)23)12-14-6-4-3-5-7-14/h3-7,13,15-17H,8-12H2,1-2H3,(H,20,21)(H,22,23)/t15-,16-,17-/m1/s1 checkY
  • Key:OELFLUMRDSZNSF-BRWVUGGUSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Nateglinide, sold under the brand name Starlix, is a medication used to treat type 2 diabetes.[2] It is used together with diet and exercise.[2] It is not a first line treatment, though may be added to metformin.[2][3] It is taken by mouth.[2]

Common side effects include dizziness, diarrhea, bronchitis, and low blood sugar.[2] Use is not recommended in those with significant liver problems.[3] Safety in pregnancy is not clear.[2] It belongs to the meglitinide class and works by stimulating the release of insulin.[1]

Nateglinide was approved for medical use in the United States in 2000 and Europe in 2001.[2][3] In the United States it costs about 30 USD per month as of 2021.[4] It is not available in the United Kingdom as of 2021.[1]

References[edit]

  1. ^ a b c d BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 742. ISBN 978-0857114105.
  2. ^ a b c d e f g h i "Nateglinide Monograph for Professionals". Drugs.com. Archived from the original on 2 September 2019. Retrieved 12 November 2021.
  3. ^ a b c "Starlix". Archived from the original on 12 November 2020. Retrieved 12 November 2021.
  4. ^ "Nateglinide Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 25 April 2020. Retrieved 12 November 2021.