User:Mr. Ibrahem/Lefamulin

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Mr. Ibrahem/Lefamulin
Clinical data
Trade namesXenleta
Other namesLefamulin acetate, BC-3781
AHFS/Drugs.comMonograph
License data
Routes of
administration		Intravenous, by mouth
Drug classAntibiotic (pleuromutilin)[1]
Legal status
Legal status
Identifiers
  • (1S,2R,3S,4S,6R,7R,8R,14R)-3-Hydroxy-2,4,7,14-tetramethyl-9-oxo-4-vinyltricyclo[5.4.3.01,8]tetradec-6-yl {[(1R,2R,4R)-4-amino-2-hydroxycyclohexyl]sulfanyl}acetate
Chemical and physical data
FormulaC28H45NO5S
Molar mass507.73 g·mol−1
3D model (JSmol)
  • C[C@@H]1CC[C@@]23CCC(=O)[C@H]2[C@@]1([C@@H](C[C@@]([C@H]([C@@H]3C)O)(C)C=C)OC(=O)CS[C@@H]4CC[C@H](C[C@H]4O)N)C
  • InChI=1S/C28H45NO5S/c1-6-26(4)14-22(34-23(32)15-35-21-8-7-18(29)13-20(21)31)27(5)16(2)9-11-28(17(3)25(26)33)12-10-19(30)24(27)28/h6,16-18,20-22,24-25,31,33H,1,7-15,29H2,2-5H3/t16-,17+,18-,20-,21-,22-,24+,25+,26-,27+,28+/m1/s1
  • Key:KPVIXBKIJXZQJX-FCEONZPQSA-N

Lefamulin, sold under the brand name Xenleta, is an antibiotic used to treat community-acquired pneumonia.[1] It is used when other antibiotics are not appropriate.[1] It is effective against a number of bacteria including MRSA.[2] It is taken by mouth or by injection into a vein.[1]

Common side effects include diarrhea, nausea, pain at the site of injection, and liver inflammation.[2] Other side effects may include QT prolongation and Clostridioides difficile infection.[2] Use during pregnancy may harm the baby.[2] It is a pleuromutilin antibiotic and works by blocking the production of proteins from bacterial RNA.[1]

Lefamulin was approved for medical use in the United States in 2019 and Europe in 2020.[3][1] In the United States a 5 day course of treatment costs about 1450 USD as of 2021.[4] While it is approved in Europe, it is not commercially available there as of 2021.[5]

References[edit]

  1. ^ a b c d e f g h "Xenleta EPAR". European Medicines Agency. 26 May 2020. Archived from the original on 9 January 2021. Retrieved 24 September 2020.
  2. ^ a b c d e f "Xenleta- lefamulin acetate injection, solution citric buffered normal saline- anhydrous citric acid injection, solution Xenleta- lefamulin acetate tablet, coated". DailyMed. 12 February 2020. Archived from the original on 6 August 2020. Retrieved 24 September 2020.
  3. ^ "Lefamulin Monograph for Professionals". Drugs.com. Archived from the original on 24 January 2021. Retrieved 21 November 2021.
  4. ^ "Xenleta Prices, Coupons & Patient Assistance Programs". Drugs.com. Archived from the original on 19 April 2021. Retrieved 21 November 2021.
  5. ^ "Lefamulin". SPS - Specialist Pharmacy Service. 14 January 2016. Archived from the original on 21 November 2021. Retrieved 21 November 2021.
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