User:Mr. Ibrahem/Isradipine

Mr. Ibrahem/Isradipine
Clinical data
Trade names	DynaCirc, Prescal
AHFS/Drugs.com	Monograph
MedlinePlus	a693048
Pregnancy; category	C;
Routes of; administration	By mouth
Drug class	Calcium channel blocker (dihydropyridine)
Legal status
Legal status	UK: POM (Prescription only); US: ℞-only;
Pharmacokinetic data
Bioavailability	15-24%
Protein binding	95%
Metabolism	100% liver
Elimination half-life	8 hours
Excretion	70% kidney, 30% fecal
Identifiers
	IUPAC name 3-methyl 5-propan-2-yl 4-(2,1,3-benzoxadiazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate;
Chemical and physical data
Formula	C19H21N3O5
Molar mass	371.393 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(OC)\C3=C(\N\C(=C(\C(=O)OC(C)C)C3c1cccc2nonc12)C)C;
	InChI InChI=1S/C19H21N3O5/c1-9(2)26-19(24)15-11(4)20-10(3)14(18(23)25-5)16(15)12-7-6-8-13-17(12)22-27-21-13/h6-9,16,20H,1-5H3 ; Key:HMJIYCCIJYRONP-UHFFFAOYSA-N ;
	(verify)

Isradipine, sold under the brand name DynaCirc among others, is a medication used to treat high blood pressure.^[1] For this use it is one of a number of first line agents.^[1] It is taken by mouth.^[1] Maximal effect may take up to four weeks.^[1]

Common side effects include headache, swelling, palpitations, and lightheadedness.^[1] Other side effects may include worsening heart failure, chest pain, and low blood pressure.^[1] Safety in pregnancy is unclear.^[2] It is a calcium channel blocker of the dihydropyridine class.^[1]

Isradipine was patented in 1978 and approved for medical use in 1989.^[3] IT is available as a generic medication.^[4] In the United States, at a dose of 5 mg twice per day, it costs about 27 USD per month.^[4]

References[edit]

^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ "Isradipine Monograph for Professionals". Drugs.com. Archived from the original on 31 August 2021. Retrieved 1 December 2021.
^ "Isradipine Use During Pregnancy". Drugs.com. Archived from the original on 24 October 2020. Retrieved 1 December 2021.
^ Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 465. ISBN 9783527607495. Archived from the original on 2021-08-27. Retrieved 2021-10-09.
^ ^a ^b "Isradipine Prices, Coupons & Savings Tips". GoodRx. Archived from the original on 20 September 2016. Retrieved 1 December 2021.

[AHFS2021-1] ^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ "Isradipine Monograph for Professionals". Drugs.com. Archived from the original on 31 August 2021. Retrieved 1 December 2021.

[2] "Isradipine Use During Pregnancy". Drugs.com. Archived from the original on 24 October 2020. Retrieved 1 December 2021.

[Fis2006-3] Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 465. ISBN 9783527607495. Archived from the original on 2021-08-27. Retrieved 2021-10-09.

[GX2021-4] "Isradipine Prices, Coupons & Savings Tips". GoodRx. Archived from the original on 20 September 2016. Retrieved 1 December 2021.

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