User:Mr. Ibrahem/Ganirelix
Clinical data | |
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Trade names | Orgalutran, Antagon, Fyremadel, others |
AHFS/Drugs.com | Monograph |
License data | |
Pregnancy category |
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Routes of administration | Subcutaneous injection |
Drug class | GnRH antagonist |
Legal status | |
Legal status | |
Pharmacokinetic data | |
Bioavailability | 91.1% |
Protein binding | 81.9% |
Elimination half-life | 16.2 hours |
Excretion | Feces: 75% Urine: 22% |
Identifiers | |
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Chemical and physical data | |
Formula | C80H113ClN18O13 |
Molar mass | 1570.35 g·mol−1 |
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Ganirelix, sold under the brand names Orgalutran among others, is a medication used in assisted reproduction to prevent early ovulation.[1] This can increase the number of suitable eggs available for in-vitro fertilisation.[1] It is given by injection under the skin.[3]
Common side effects include abdominal pain, headache, vaginal bleeding, nausea, and ovarian hyperstimulation syndrome.[2] It should not be used in those with latex allergies.[4] It should not be used once pregnancy has occurred.[2] It is a gonadotropin-releasing hormone (GnRH) antagonist.[3] It works by blocking receptors for GnRH, which decreases LH and therefore stops ovulation until this is desired.[1]
Ganirelix was approved for medical use in the United States in 1999 and Europe in 2000.[2][1] In the United States 5 doses of 0.25 mg costs about 380 USD as of 2021.[5]
References[edit]
- ^ a b c d e "Orgalutran". Archived from the original on 12 November 2020. Retrieved 3 December 2021.
- ^ a b c d "Ganirelix Monograph for Professionals". Drugs.com. Archived from the original on 21 January 2021. Retrieved 3 December 2021.
- ^ a b BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 778. ISBN 978-0857114105.
- ^ Canada, Health (29 August 2018). "Health Product InfoWatch - September 2018". www.canada.ca. Archived from the original on 3 November 2021. Retrieved 3 December 2021.
- ^ "Ganirelix Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 23 April 2017. Retrieved 3 December 2021.