User:Mr. Ibrahem/Fluticasone propionate

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For other uses, see Fluticasone.
Mr. Ibrahem/Fluticasone propionate
Clinical data
Trade namesFlovent, Flixotide, Flonase, others
AHFS/Drugs.comMonograph
MedlinePlusa695002
License data
Pregnancy
category
Routes of
administration		Intranasal,[2] inhaled,[3] topical[4]
Drug classSteroids and steroid derivatives
Legal status
Legal status
Pharmacokinetic data
Bioavailability0.51% (intranasal)
Protein binding91%
MetabolismIntranasal
Liver (CYP3A4-mediated)
Elimination half-life10 hours
ExcretionKidney
Identifiers
  • S-(fluoromethyl)-6α,9-difluoro-11β, 17-dihydroxy-16α-methyl-3-oxoandrosta-1, 4-diene-17β-carbothioate, 17-propanoate
Chemical and physical data
FormulaC25H31F3O5S
Molar mass500.57 g·mol−1
3D model (JSmol)
  • CCC(=O)OC1(C(CC2C1(CC(C3(C2CC(C4=CC(=O)C=CC43C)F)F)O)C)C)C(=O)SCF
  • InChI=1S/C25H31F3O5S/c1-5-20(31)33-25(21(32)34-12-26)13(2)8-15-16-10-18(27)17-9-14(29)6-7-22(17,3)24(16,28)19(30)11-23(15,25)4/h6-7,9,13,15-16,18-19,30H,5,8,10-12H2,1-4H3/t13-,15+,16+,18+,19+,22+,23+,24+,25+/m1/s1 checkY
  • Key:WMWTYOKRWGGJOA-CENSZEJFSA-N checkY
  (verify)

Fluticasone propionate, sold under the brand names Flovent and Flonase among others, is a steroid medication.[8] When inhaled it is used for the long term management of asthma and COPD.[8] In the nose it is used for hay fever and nasal polyps.[9][10] It can also be used for mouth ulcers.[11]

Common side effects when inhaled include upper respiratory tract infections, sinusitis, thrush, and cough.[8] Common side effects when used in the nose include nosebleeding and sore throat.[9] It works by decreasing inflammation.[8]

Fluticasone propionate was patented in 1980, and approved for medical use in 1990.[12] It is available as a generic medication.[10] In the United States the wholesale cost per spray is about 0.33 USD as of 2018.[13] In the United Kingdom, it costs the NHS about 0.13 GBP per spray as of 2019.[10] In 2018, it was the sixteenth most commonly prescribed medication in the United States, with more than 34 million prescriptions.[14][15]

References[edit]

  1. ^ a b "Fluticasone Use During Pregnancy". Drugs.com. 9 January 2019. Archived from the original on 26 March 2019. Retrieved 31 January 2020.
  2. ^ "Flonase Allergy Relief- fluticasone propionate spray, metered". DailyMed. 30 May 2019. Archived from the original on 2 December 2020. Retrieved 31 January 2020.
  3. ^ "Flovent Diskus- fluticasone propionate powder, metered". DailyMed. 7 January 2019. Archived from the original on 7 December 2019. Retrieved 31 January 2020.
  4. ^ "Cutivate- fluticasone propionate ointment". DailyMed. 18 February 2019. Archived from the original on 28 August 2021. Retrieved 31 January 2020.
  5. ^ "Flixonase Aqueous Nasal Spray - Summary of Product Characteristics (SmPC)". (emc). 25 October 2019. Archived from the original on 31 January 2020. Retrieved 31 January 2020.
  6. ^ "WHOCC - ATC/DDD Index". www.whocc.no. Archived from the original on 19 August 2020. Retrieved 9 September 2020.
  7. ^ "WHOCC - ATC/DDD Index". www.whocc.no. Archived from the original on 20 August 2020. Retrieved 9 September 2020.
  8. ^ a b c d "Fluticasone Propionate Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 28 February 2019. Retrieved 27 February 2019.
  9. ^ a b "Fluticasone Propionate eent Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 28 February 2019. Retrieved 27 February 2019.
  10. ^ a b c British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. pp. 262, 1172. ISBN 9780857113382.
  11. ^ "Flixonase aqueous spray" (PDF). Sheffield Teaching Hospitals. June 2018. Archived (PDF) from the original on 25 September 2019. Retrieved 31 January 2020.
  12. ^ Fischer, János; Ganellin, C. Robin (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 487. ISBN 9783527607495. Archived from the original on 28 February 2019. Retrieved 28 February 2019.
  13. ^ "NADAC as of 2018-12-19". Centers for Medicare and Medicaid Services. Archived from the original on 19 December 2018. Retrieved 22 December 2018.
  14. ^ "The Top 300 of 2021". ClinCalc. Archived from the original on 12 February 2021. Retrieved 18 February 2021.
  15. ^ "Fluticasone - Drug Usage Statistics". ClinCalc. Archived from the original on 12 April 2020. Retrieved 18 February 2021.
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