User:Mr. Ibrahem/Cefiderocol

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Mr. Ibrahem/Cefiderocol
Clinical data
Trade namesFetroja, Fetcroja
Other namesCephiderocol, RSC-649266
AHFS/Drugs.comMonograph
MedlinePlusa620008
License data
Routes of
administration		Intravenous infusion
Drug classSiderophore cephalosporin[1]
Legal status
Legal status
  • US: ℞-only
  • EU: Rx-only
  • In general: ℞ (Prescription only)
Pharmacokinetic data
Protein binding56–58%[2]
Elimination half-life2.8 hours
ExcretionMainly kidney (60–70% unchanged)
Identifiers
  • (6R,7R)-7-[[(2Z)-2-(2-Amino-1,3-thiazol-4-yl)-2-(2-carboxypropan-2-yloxyimino)acetyl]amino]-3-[[1-[2-[(2-chloro-3,4-dihydroxybenzoyl)amino]ethyl]pyrrolidin-1-ium-1-yl]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
Chemical and physical data
FormulaC30H34ClN7O10S2
Molar mass752.21 g·mol−1
3D model (JSmol)
  • CC(C)(C(=O)O)ON=C(C1=CSC(=N1)N)C(=O)NC2C3N(C2=O)C(=C(CS3)C[N+]4(CCCC4)CCNC(=O)C5=C(C(=C(C=C5)O)O)Cl)C(=O)[O-]
  • InChI=1S/C30H34ClN7O10S2/c1-30(2,28(46)47)48-36-19(16-13-50-29(32)34-16)24(42)35-20-25(43)37-21(27(44)45)14(12-49-26(20)37)11-38(8-3-4-9-38)10-7-33-23(41)15-5-6-17(39)22(40)18(15)31/h5-6,13,20,26H,3-4,7-12H2,1-2H3,(H7-,32,33,34,35,36,39,40,41,42,44,45,46,47)/t20-,26-/m1/s1
  • Key:DBPPRLRVDVJOCL-FQRUVTKNSA-N

Cefiderocol, sold under the brand name Fetroja among others, is an antibiotic used to treat complicated urinary tract infections and hospital acquired pneumonia.[3] It is used when other treatments might not work, including for Pseudomonas aeruginosa.[4][3] It is given by injection into a vein.[3]

Common side effects include diarrhea, pain at the site of injection, constipation, rash, candidiasis, liver problems, and low potassium.[3] Other side effects may include anaphylaxis, Clostridioides difficile infection, and seizures.[3] Safety in pregnancy is unclear.[3] It is in the cephalosporin family of medications.[3]

Cefiderocol was approved for medical use in the United States in 2019 and Europe in 2020.[3][4] It is on the World Health Organization's List of Essential Medicines.[5] In the United Kingdom 5 doses costs about £1,300.[6] This amount in the United States is about 2,000 USD.[7]

References[edit]

  1. ^ "Cefiderocol Monograph for Professionals". Drugs.com. Archived from the original on 21 January 2021. Retrieved 30 December 2021.
  2. ^ Katsube, T.; Echols, R.; Arjona Ferreira, J. C.; et al. (2017). "Cefiderocol, a Siderophore Cephalosporin for Gram‐Negative Bacterial Infections: Pharmacokinetics and Safety in Subjects With Renal Impairment". Journal of Clinical Pharmacology. 57 (5): 584–591. doi:10.1002/jcph.841. PMC 5412848. PMID 27874971.
  3. ^ a b c d e f g h i j "Fetroja- cefiderocol sulfate tosylate injection, powder, for solution". DailyMed. 19 November 2019. Archived from the original on 1 February 2021. Retrieved 29 April 2020.
  4. ^ a b c "Fetcroja EPAR". European Medicines Agency (EMA). 24 February 2020. Archived from the original on 17 September 2020. Retrieved 29 April 2020. Public Domain This article incorporates text from this source, which is in the public domain.
  5. ^ World Health Organization (2021). World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. hdl:10665/345533. WHO/MHP/HPS/EML/2021.02.
  6. ^ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 562. ISBN 978-0857114105.
  7. ^ "Fetroja Prices, Coupons & Patient Assistance Programs". Drugs.com. Retrieved 30 December 2021.
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