User:Mr. Ibrahem/Cefaclor

Mr. Ibrahem/Cefaclor
Clinical data
Trade names	Distaclor, Medacef, Keflor, others
Other names	Cephaclor
AHFS/Drugs.com	Monograph
MedlinePlus	a682729
Pregnancy; category	AU: B1; ;
Routes of; administration	By mouth
Drug class	Antibiotic (2nd generation cephalosporin)
Legal status
Legal status	In general: ℞ (Prescription only);
Pharmacokinetic data
Bioavailability	Well absorbed, independent of food intake
Metabolism	15% to 40%
Elimination half-life	0.6 to 0.9 hours
Excretion	Kidney
Identifiers
	IUPAC name (6R,7R)-7-{[(2R)-2-amino-2-phenylacetyl]amino}- 3-chloro-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene- 2-carboxylic acid;
Chemical and physical data
Formula	C15H14ClN3O4S
Molar mass	367.80 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C2N1/C(=C(/Cl)CS[C@@H]1[C@@H]2NC(=O)[C@@H](c3ccccc3)N)C(=O)O.O;
	InChI InChI=1S/C15H14ClN3O4S.H2O/c16-8-6-24-14-10(13(21)19(14)11(8)15(22)23)18-12(20)9(17)7-4-2-1-3-5-7;/h1-5,9-10,14H,6,17H2,(H,18,20)(H,22,23);1H2/t9-,10-,14-;/m1./s1 ; Key:WKJGTOYAEQDNIA-IOOZKYRYSA-N ;
	(what is this?) (verify)

Cefaclor, sold under the brand name Ceclor among others, is an antibiotic used to treat bacterial infections such as pneumonia, middle ear infections, strep throat, cellulitis, and urinary tract infections.^[4] It is taken by mouth with food.^[1] It may be used in children as young as a month old.^[1]

Common side effects include rash, diarrhea, vaginitis, nausea, and headache.^[4] Other side effects may include anxiety, low red blood cells, joint pains, allergic reactions, jaundice, and swollen glands.^[1] It is not known to cause harm in pregnancy and may be used when breastfeeding.^[1] It is a second-generation cephalosporin.^[3]

Cefaclor was patented in 1975 and approved for medical use in 1979.^[5]^[6] In the United Kingdom, a course of treatment generally costs the NHS less than £10, as of 2021.^[1] This amount in the United States costs about 22 USD.^[7]

References[edit]

^ ^a ^b ^c ^d ^e ^f "5. Infection". British National Formulary (BNF) (82 ed.). London: BMJ Group and the Pharmaceutical Press. September 2021 – March 2022. pp. 559–560. ISBN 978-0-85711-413-6.{{cite book}}: CS1 maint: date format (link)
^ "A - Z Drug List from Drugs.com: Cefaclor". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 17 November 2021. Retrieved 27 November 2021.
^ ^a ^b Beauduy, Camille E.; Winston, Lisa G. (2020). "43. Beta-lactam and other cell wall - & membrane - active antibiotics". In Katzung, Bertram G.; Trevor, Anthony J. (eds.). Basic and Clinical Pharmacology (15th ed.). New York: McGraw-Hill. pp. 832–834. ISBN 978-1-260-45231-0. Archived from the original on 2021-10-10. Retrieved 2021-11-27.
^ ^a ^b ^c ^d "Cefaclor Monograph for Professionals". Drugs.com. Archived from the original on 26 February 2021. Retrieved 30 December 2021.
^ Nard, Craig Allen (2020). "7. Enforcing patent rights". The Law of Patents. New York: Wolters Kluwer. p. 694. ISBN 978-1-5438-1368-5. Archived from the original on 2021-12-11. Retrieved 2021-12-01.
^ Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 493. ISBN 9783527607495. Archived from the original on 2017-09-10. Retrieved 2020-12-31.
^ "Cefaclor Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 30 December 2021.

[BNF82-1] ^ ^a ^b ^c ^d ^e ^f "5. Infection". British National Formulary (BNF) (82 ed.). London: BMJ Group and the Pharmaceutical Press. September 2021 – March 2022. pp. 559–560. ISBN 978-0-85711-413-6.{{cite book}}: CS1 maint: date format (link)

[AHFS-2] "A - Z Drug List from Drugs.com: Cefaclor". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 17 November 2021. Retrieved 27 November 2021.

[Katzung2021-3] Beauduy, Camille E.; Winston, Lisa G. (2020). "43. Beta-lactam and other cell wall - & membrane - active antibiotics". In Katzung, Bertram G.; Trevor, Anthony J. (eds.). Basic and Clinical Pharmacology (15th ed.). New York: McGraw-Hill. pp. 832–834. ISBN 978-1-260-45231-0. Archived from the original on 2021-10-10. Retrieved 2021-11-27.

[AHFS2021-4] "Cefaclor Monograph for Professionals". Drugs.com. Archived from the original on 26 February 2021. Retrieved 30 December 2021.

[Nard2020-5] Nard, Craig Allen (2020). "7. Enforcing patent rights". The Law of Patents. New York: Wolters Kluwer. p. 694. ISBN 978-1-5438-1368-5. Archived from the original on 2021-12-11. Retrieved 2021-12-01.

[Fis2006-6] Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 493. ISBN 9783527607495. Archived from the original on 2017-09-10. Retrieved 2020-12-31.

[7] "Cefaclor Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 30 December 2021.

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