User:Mr. Ibrahem/Caspofungin

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Mr. Ibrahem/Caspofungin
Clinical data
Pronunciation/ˌkæspoʊˈfʌndʒɪn/ KAS-poh-FUN-jin
Trade namesCancidas
AHFS/Drugs.comMonograph
License data
Pregnancy
category
  • AU: B3
Routes of
administration		Intravenous
Legal status
Legal status
  • US: ℞-only
  • EU: Rx-only
  • In general: ℞ (Prescription only)
Pharmacokinetic data
Bioavailability100% (intravenous use only)
Protein binding~97%
MetabolismLiver
Elimination half-life9–11 hours
ExcretionUrine (41%), feces (35%)
Identifiers
  • (10R,12S)-N-{(2R,6S,9S,11R,12S,14aS,15S,20S,23S,25aS)-12-[(2-Aminoethyl)amino]-20-[(1R)-3-amino-1-hydroxypropyl]-23-[(1S,2S)-1,2-dihydroxy-2-(4-hydroxyphenyl)ethyl]-2,11,15-trihydroxy-6-[(1R)-1-hydroxyethyl]-5,8,14,19,22,25-hexaoxotetracosahydro-1H-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacyclohenicosin-9-yl}-10,12-dimethyltetradecanamide
Chemical and physical data
FormulaC52H88N10O15
Molar mass1093.331 g·mol−1
3D model (JSmol)
  • [C@@]12(N(C[C@@H](C1)O)C([C@H]([C@@H](C)O)NC(=O)[C@](C[C@H]([C@@H](NCCN)NC([C@@H]3[C@H](CCN3C([C@H]([C@@H](CCN)O)NC(=O)[C@H]([C@@H]([C@H](C4=CC=C(C=C4)O)O)O)NC2=O)=O)O)=O)O)(NC(CCCCCCCC[C@H](C[C@H](CC)C)C)=O)[H])=O)[H]
  • InChI=1S/C52H88N10O15/c1-5-28(2)24-29(3)12-10-8-6-7-9-11-13-39(69)56-34-26-38(68)46(55-22-21-54)60-50(75)43-37(67)19-23-61(43)52(77)41(36(66)18-20-53)58-49(74)42(45(71)44(70)31-14-16-32(64)17-15-31)59-48(73)35-25-33(65)27-62(35)51(76)40(30(4)63)57-47(34)72/h14-17,28-30,33-38,40-46,55,63-68,70-71H,5-13,18-27,53-54H2,1-4H3,(H,56,69)(H,57,72)(H,58,74)(H,59,73)(H,60,75)/t28-,29+,30+,33+,34-,35-,36+,37-,38+,40-,41-,42-,43-,44-,45-,46-/m0/s1 checkY
  • Key:JYIKNQVWKBUSNH-WVDDFWQHSA-N checkY
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Caspofungin, sold under the brand name Cancidas, is a medication used to treat fungal infections such as candidiasis and aspergillosis.[1] It may be used in people with low neutrophils.[1] It is given by injection into a vein.[1]

Common side effects include diarrhea, fever, liver problems, and low potassium.[2] Other side effects may include anaphylaxis and Stevens-Johnson syndrome.[2] Use in pregnancy may harm the baby.[2] It is a antifungal of the lipopeptide and echinocandin class.[3] It works by interfering with the cell wall of the fungus.[3]

Caspofungin was approved for medical use in the United States and Europe in 2001.[3][4] It is on the World Health Organization's List of Essential Medicines as an alternative to micafungin.[5] It is available as a generic medication.[1] In the United Kingdom it costs about £50 as of 2021.[1] This amount in the United States is about 60 USD.[6]

References[edit]

  1. ^ a b c d e f BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 632. ISBN 978-0857114105.
  2. ^ a b c d "DailyMed - CASPOFUNGIN ACETATE injection". dailymed.nlm.nih.gov. Archived from the original on 1 April 2021. Retrieved 30 December 2021.
  3. ^ a b c "Caspofungin Monograph for Professionals". Drugs.com. Archived from the original on 23 April 2021. Retrieved 30 December 2021.
  4. ^ "Cancidas (previously Caspofungin MSD)". Archived from the original on 10 November 2021. Retrieved 30 December 2021.
  5. ^ World Health Organization (2021). World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. hdl:10665/345533. WHO/MHP/HPS/EML/2021.02.
  6. ^ "Caspofungin Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 30 December 2021.
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