User:Mr. Ibrahem/Bepotastine

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Mr. Ibrahem/Bepotastine
Clinical data
Pronunciationbep oh tas' teen
Trade namesBepreve[1]
Other namesBepotastine besilate
AHFS/Drugs.comMonograph
MedlinePlusa610012
Routes of
administration		By mouth, eye drops
Drug classAntihistamine, hay fever, hives[2][1]
Legal status
Legal status
  • In general: ℞ (Prescription only)
Pharmacokinetic data
BioavailabilityHigh (by mouth)
Minimal (topical)
Protein binding~55%
ExcretionRenal (75–85
Identifiers
  • 4-[4-[(4-chlorophenyl)-pyridin-2-ylmethoxy]piperidin-1-yl]butanoic acid
Chemical and physical data
FormulaC21H25ClN2O3
Molar mass388.89 g·mol−1
3D model (JSmol)
  • Clc1ccc(cc1)C(OC2CCN(CCCC(=O)O)CC2)c3ncccc3
  • InChI=1S/C21H25ClN2O3/c22-17-8-6-16(7-9-17)21(19-4-1-2-12-23-19)27-18-10-14-24(15-11-18)13-3-5-20(25)26/h1-2,4,6-9,12,18,21H,3,5,10-11,13-15H2,(H,25,26) checkY
  • Key:YWGDOWXRIALTES-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Bepotastine, sold under the brand names Bepreve among others, is a medication used as an eye drop to treat allergic conjunctivitis.[1] By mouth it may be used for allergic rhinitis (hay fever) and hives.[2]

Common side effects eye irritation, headache, and stuffy nose.[3] While there is no evidence of harm in pregnancy, such use has not been well studied.[3][4] It is an antihistamine and mast cell stabilizer.[1]

Bepotastine was approved for medical use in Japan in 2000 and the United States in 2009.[2][3] In the United States 5 ml for the eyes costs about 70 USD as of 2022.[5]

References[edit]

  1. ^ a b c d e "Bepotastine Monograph for Professionals". Drugs.com. Archived from the original on 27 October 2021. Retrieved 24 November 2021.
  2. ^ a b c Leung, Donald Y. M.; Sampson, Hugh; Geha, Raif; Szefler, Stanley J. (13 October 2010). Pediatric Allergy: Principles and Practice E-Book. Elsevier Health Sciences. ISBN 978-1-4377-3778-3. Archived from the original on 11 January 2022. Retrieved 9 January 2022.
  3. ^ a b c d "DailyMed - BEPOTASTINE BESILATE solution/ drops". dailymed.nlm.nih.gov. Archived from the original on 11 January 2022. Retrieved 9 January 2022.
  4. ^ "Bepotastine ophthalmic (Bepreve) Use During Pregnancy". Drugs.com. Archived from the original on 25 October 2021. Retrieved 9 January 2022.
  5. ^ "Bepotastine Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 23 August 2016. Retrieved 9 January 2022.
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