Talk:S100A10

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p11 wiki project[edit]

Hi, I'm a student of an Intro to neuroscience class, my group and I are assigned by the professor to expand the P11 protein stub, which is the same protein as s100a10. So we thought of merging this article with ours. You got some good information/picture in this stub and I would appreciate if you could tell me how we could get more pictures of the s100a10 protein under proper conditions to make this article more complete. Btw we are trying to get this article featured and any help from you will be greatly appreciated. After all we are trying to get the public informed.

-kris —Preceding unsigned comment added by Kristaqkoci (talk • contribs) 07:24, 28 October 2009 (UTC)[reply]

Nice start on your class project. I took the liberty of merging the p11 protein article with this article since they concern the same subject. I did not include most of the information on Paul Greengard since (1) he is not the discoverer of the p11 protein and (2) the focus of the article should remain on the protein and not the discoverers. In addition, I have the following suggestions:

While promoting this article to WP:Featured status is a noble goal, I don't think it is a reasonable one in the time frame of your course. Normally an article must first be promoted to WP:Good status even before Featured would be considered. I think WP:Good is a much more realistic goal and I think you should communicate this suggestion to your instructor.
If you haven't seen this yet, please check out User:Diberri's Wikipedia template filling tool. Given a PubMedID, one can quickly produced a full citation that can be copy and pasted into a Wikipedia article. This will save you an enormous amount of work and insures that the citations are displayed in a consistent manor.
Concerning graphics of the p11 protein, I have updated the one in the protein box using PyMol which is an open source program. I believe academics and students can get a ready to run compiled version for free. So in principle you could create your own graphics using PyMol, but this may be somewhat outside the scope of your neuroscience class. If I find the time, I may be able to supply you with more figures.

Good luck on your project. Cheers. Boghog (talk) 19:00, 29 October 2009 (UTC)[reply]

How can we get this article posted in the peer review section?

I think you meant WP:Good and if so, see WP:GAN. For peer review, see WP:PR. Please note that any type of review is a lot of work for the reviewers and it is expected that you respond to their suggestions by improving the article. Boghog (talk) 07:44, 3 December 2009 (UTC)[reply]

Peer review from BI481 classmates[edit]

Comment 1[edit]

I think you guys did a good job explaining p11’s role in depression. However, I feel like you guys may want to expand on your “regulation of transcription” section. I found an article called “Dexamethasone Alters Arachidonate Release from Human Epithelial Cells by Induction of p11 Protein Synthesis and Inhibition of Phospholipase A2 Activity” which can help you expand on how glucocorticosteroids, such as dexamethasone, affect the expression of p11. Also, there seems to be a lot of research done on how increased p11 levels can inhibit cytosolic phospholipase A and alter the release of arachidonic acid, which serves as an intermediate in the inflammatory response. Thus, you may want to talk about how p11 can play a role in anti-inflammatory drugs as well.

As a side note, I noticed that two sentences were repeated in the last two paragraphs under “Clinical Significance.” You may want to delete the repeated sentences.

Gandhi7 (talk) 17:00, 28 November 2009 (UTC)[reply]

Thanks! We'll look into more research on that! We appreciate your feedback =) Fdemsas (talk) 20:19, 29 November 2009 (UTC)[reply]

Comment 2[edit]

I thought the article was informative and very useful for gaining some basic knowledge of p11. My main suggestion is regarding the "Function" section. Since it p11 is found mainly in the lungs and kidney, it has other important functions in addition to regulating serotonin release. This relatively recent review article lists a couple of other important functions of p11 especially it's role in trafficking plasma membrane proteins:

Rescher U, Gerke V (2008). "S100A10/p11: family, friends and functions" (PDF). Pflugers Arch. 455 (4): 575–82. doi:10.1007/s00424-007-0313-4. PMID 17638009. {{cite journal}}: Unknown parameter |month= ignored (help)

Also, some information in the clinical significance section seems to be repeated several times during the section. It may be helpful to make it a little more concise.

Rabihgeha (talk) 17:51, 29 November 2009 (UTC)Rabihgeha[reply]

Thank you, we'll make those corrections and look up that article. Your comments are much appreciated! Fdemsas (talk) 20:19, 29 November 2009 (UTC)[reply]

Comment 3[edit]

I thought this was a great article overall. So my suggestions are small ones. I noticed that you guys summarize an article (the one linking depression and the p11 expression) in the introduction section, but the same topic is talked about in the clinical significance section. I agree with Rabihgeha, perhaps it doesn’t need to be as detailed in the intro section? Also, the clinical significance is a bit long, maybe it could be broken down into subsections dealing with the pathology and the possible treatments? That might make it a bit easier to digest. That’s all, again, good job!

Philipthegreat88 (talk) 23:27, 29 November 2009 (UTC)[reply]

Comment 4[edit]

This article is very well-written and interesting to read. The only suggestion I have is that the "diverse systems" mentioned in the clinical significance section should be mentioned in the function section, perhaps by splitting this section into Function in the CNS and elsewhere. As an example, I found a good article when doing my own wiki article titled:
- Foulkes T, Nassar MA, Lane T, Matthews EA, Baker MD, Gerke V, Okuse K, Dickenson AH, Wood JN (2006). "Deletion of annexin 2 light chain p11 in nociceptors causes deficits in somatosensory coding and pain behavior". J. Neurosci. 26 (41): 10499–507. doi:10.1523/JNEUROSCI.1997-06.2006. PMID 17035534. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link) This journal discusses the importance of p11 in pain behaviors, specifically in trafficking of Na+ and K+ ion channels.
To further the above comment, the 5th paragraph in this section seems to be repetitive. On a side note, I found a small error in the 4th paragraph of the Clinical Significance section, "synaptic clef" should be "synaptic cleft". And in this sentence, 'the' should be 'they', and it could be cleaned up a bit: "When researchers molecularly removed or "knocked out" the p11 gene in mice, the found that the knockout mice had fewer receptors at the cell surface, less serotonin signaling, reduced responsiveness to sweet reward, and less mobile behaviors all characteristic of depression-like behaviors."

Bellamen (talk) 00:09, 30 November 2009 (UTC)[reply]

Lead sentence[edit]

In addition to humans, the S100-A10 protein is expressed in many other animals. Therefore the statement "S100-A10 protein is encoded by the human S100A10 gene" is very misleading. I have therefore edited the lead sentence to make clear that the protein is expressed not only in humans but also in other species. Cheers. Boghog (talk) 07:34, 6 December 2009 (UTC)[reply]