Talk:Human challenge study

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Quote[edit]

I think this quote belongs in the article, perhaps in a section devoted to its use in studying disease transmission: "Challenge studies are also used to study processes of infection and immunity from their inception (5). They could thus be used to (a) validate tests for immunity to SARS-CoV-2, (b) identify correlates of immune protection, and (c) investigate the risks of transmission posed by infected individuals(4, 10). Such findings could significantly improve the overall public health response to the pandemic. This document aims to provide guidance to scientists, research ethics committees, funders, policy-makers, and regulators in deliberations regarding SARS-CoV-2 challenge studies by outlining key criteria that would need to be satisfied in order for such studies to be ethically acceptable." What do you think? Here's the source: https://www.who.int/ethics/publications/key-criteria-ethical-acceptability-of-covid-19-human-challenge/en/General Student 21 (talk) 21:08, 18 May 2020 (UTC)[reply]

Viral exposure[edit]

Would it not be better to speak of exposing people to an infectious agent? After all, to get infected the subjects immune system needs to be overwhelmed which often does not happen. It sounds so much worse when you say deliberately infect, as if the have no chance of staying healthy, and it is misleading. In order to be neutral we need to guard against inaccurate represenations like that. General Student 21 (talk) 21:21, 18 May 2020 (UTC)[reply]

Maybe we should bear in mind that there are many causes of the death of a volunteer in an challenge study, besides the action of the researchers. I mean the "blame" if any can also be put on: the virus (the enemy if you like) which would have killed even more people were it not for the challenge study; the cells of the volunteer which are stupid enough to obey the RNA of the virus; the immune system of the volunteer that was not competent enough; the volunteer that made the decision to take part; the authorities for not containing the virus when it was a small outbreak in one city. We don't say British pilots in WW2 were killed by the British government, or their commanding officers, we say bullets or the Germans killed them - anything else would be POV.General Student 21 (talk) 21:33, 18 May 2020 (UTC)[reply]

Ethics[edit]

How about an ethics section? General Student 21 (talk) 21:48, 18 May 2020 (UTC)[reply]

@General Student 21: Yo yo you can edit Wikipedia and add things like this. For this time I just added an ethics section at your request. Please contribute. Blue Rasberry (talk) 15:16, 16 August 2020 (UTC)[reply]

The WHO guideline directly addressed ethics, and articles by the bioethicist, Nir Eyal - e.g., PMID 32232474 - are useful. Zefr (talk) 15:40, 16 August 2020 (UTC)[reply]

Alternative name[edit]

I just added information saying that "human challenge study" and "controlled human infection model" are the same thing. Here are some sources which say this incidentally. I have no identified a source which defines the concept and authoritatively says these are the same.

If anyone sees a difference then please speak up about what that is. Blue Rasberry (talk) 15:02, 16 August 2020 (UTC)[reply]

Broken link to Covid-19 Vaccine article[edit]

The "Proposed Challenge Studies" section in the COVID-19 vaccine article does not exist. The following link should be corrected or removed from this article. https://en.wikipedia.org/wiki/COVID-19_vaccine#Proposed_challenge_studies WhatWouldKantDo (talk) 20:17, 8 March 2021 (UTC)[reply]