Talk:Drug delivery

HELLO my name is FAWZIYAH BINISMAEIL in first-year master's degree student in the molecular biology department im doing this editing for coursework for Recent Developments in Biotechnology — Preceding unsigned comment added by Fouziyah binismaeil (talk •

the link of the

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Pharmacology Mid‑importance

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Chemical and Bio Engineering (inactive)

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Wiki Education Foundation-supported course assignment[edit]

This article was the subject of a Wiki Education Foundation-supported course assignment, between 1 January 2021 and 1 June 2021. Further details are available on the course page. Student editor(s): Doxycycle.

Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 19:52, 16 January 2022 (UTC)[reply]

Proposed Merge[edit]

It seems to me that Drug delivery and Route of administration are on the same topic. I suggest that these articles should be merged with appropriate redirects.-- aBSuRDiST -^T J ^C- 23:47, 21 July 2007 (UTC)[reply]

I do not think it is correct to merge the two articles. Drug delivery is completely different to Route of administration. Drug delivery refers to various carriers used to make the current treatment modalities more effective and the other one is various routes available for drug administration. —The preceding unsigned comment was added by 76.195.209.11 (talk) 05:20, August 21, 2007 (UTC)

I would not merge the articles. Drug delivery usually refers to the technologies which enable administration of drug compounds through various routes. It also refers to different methods of administration within the same route (injection - depot, IV, IP, bolus, infusion...) When preferred routes do not provide the desired efficacy or toxicity, then drug delivery technologies may be employed. 68windmills 23:46, 14 September 2007 (UTC)[reply]

As it looks right now i would definitely merge the articles - but in general drug administration is different from drug delivery. Drug administration routes include intravenous, oral, rectal, sublingual, buccal, pulmonal, subcutaneous, vaginal, topical and others. Basically, these are different strategies for getting the active compound into the bloodstream or lymph system. Drug delivery on the other hand covers technologies to enhance the specific accumulation of active compound at the site of disease. Drug delivery systems alter the pharmacokinetics and biodistribution of a drug and thus increase its effect. They can protect the drug from degradation (e.g. conjugation), protect the patient from adverse effects (e.g. sustained release), passively increase the amount of drug at the site of disease (e.g liposomes in tumors) or actively target drugs to certain tissues (e.g. antibody-conjugates). —Preceding unsigned comment added by 85.81.181.65 (talk) 20:05, 11 November 2007 (UTC)[reply]

Drug delivery and Route of administration are definetively differents topics. In case the articles will be merged this has to be clearly taken into consideration. --217.95.255.143 (talk) 18:55, 28 November 2007 (UTC)[reply]

Thanks for all your comments. It seems the consensus is to not merge. I will remove the tags. -- aBSuRDiST -^T ☺ ^C- 12:27, 24 February 2008 (UTC)[reply]

Improving clarity of the information provided[edit]

It seems to me that certain changes could be made to the body of this article which could either improve the article's clarity or reduce ambiguity. Some of more elaborative information which I have removed (such as the final sentence concerning survival of some agents in the stomach) would seem more suitable if subsections were created.

Drug delivery refers to approaches, formulations, technologies, and systems for transporting a pharmaceutical compound in the body as needed to safely achieve its desired therapeutic effect. Quantity of drug, duration of drug presence, target specificity, and systemic pharmacokinetics are of primary concern when developing new drug delivery methods. Drug delivery is a concept heavily integrated with dosage form and route of administration, the latter sometimes even being considered part of the definition.

Drug delivery technologies are aimed at modifying a drug's pharmacokinetic profile (absorption, distribution, metabolism, and excretion) for the benefit of improving product efficacy and safety as well as patient convenience and compliance. Some methods of drug release include diffusion, degradation, and affinity-based mechanisms. Common routes of administration include peroral (through the mouth), topical (skin), transmucosal (nasal, buccal/sublingual, vaginal, ocular, and rectal), and inhalation routes. Many medications involving peptide, protein, antibody, vaccine, and gene based drugs may not be delivered using these routes due to factors such as succeptibility to enzymatic degradation or poor bioavailability. For this reason, many of these drugs have to be delivered by injection.

Current efforts in the area of drug delivery include the development of targeted delivery in which the drug is only active in the target area of the body (for example, in cancerous tissues), sustained release formulations in which the drug is released over a period of time in a controlled manner, and methods to increase survival of peroral agents which must pass through the stomach's acidic environment. In order to achieve efficient targeted delivery, the designed system must avoid the host's defense mechanisms and circulate to its intended site of action.

--AustinR17 (talk) 22:14, 20 April 2016 (UTC)[reply]

It seems to me that this article is clear, concise and easy to read. It can be better if its is broken down into sections to reflect different point. --Kairui jiang (talk) 21:00, 17 June 2020 (UTC)[reply]

Article Overhaul[edit]

Hello all, I recently edited this article as a part of the WikiEdu program. I reorganized most of the information that was previously present in the article, and removed some of it as it was very specific and not totally necessary in my opinion. For example, there previously were several sentences talking about difficulties with getting peptide drugs into the cytosol. This does not seem like something that belongs in the article (at least not just thrown into the body of the article as it previously was). I also added a lot; see the edit history for all edits that were made. There was a lot of uncited information in the previous article, I have fixed that issue now. I think it may also be beneficial to add a "History" heading, and potentially look into talking about the processes involved in drug delivery. There are also many more types of delivery systems currently being researched that could be mentioned in the article, however I do not currently have the time to do this myself so I focused on what I thought was most necessary. If anyone disagrees with any edits I made, feel free to undo the ones you disagree with or simply add in the information yourself. --Doxycycle (talk) 21:23, 28 April 2021 (UTC)[reply]