Butyrylnorfentanyl

Butyrylnorfentanyl
Identifiers
	IUPAC name N-phenyl-N-4-piperidinyl-butanamide,;
CAS Number	1432-03-7;
PubChem CID	10658099;
ChemSpider	3442746 ;
Chemical and physical data
Formula	C15H22N2O
Molar mass	246.354 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(N(C1=CC=CC=C1)C2CCNCC2)CCC;
	InChI InChI=1S/C15H22N2O.ClH/c1-2-6-15(18)17(13-7-4-3-5-8-13)14-9-11-16-12-10-14;/h3-5,7-8,14,16H,2,6,9-12H2,1H3;1H; Key:VVVKOVYWEOKXGV-UHFFFAOYSA-N;

Butyrnorfentanyl or butyrylnorfentanyl is an inactive synthetic opioid analgesic drug precursor. It is an analog of fentanyl.^[1]^[2]^[3]^[4]^[5]^[6]^[7]^[8]^[9]^[10]

References[edit]

^ Strayer KE (2018). "LC-MS/MS-based method for the multiplex detection of 24 fentanyl analogues and metabolites in whole blood at sub ng mL–1 concentrations". ACS Omega. 3 (1): 514–523. doi:10.1021/acsomega.7b01536. PMC 5793031. PMID 29399650.
^ Mannocchi G (2020). "Development and validation of fast UHPLC-MS/MS screening method for 87 NPS and 32 other drugs of abuse in hair and nails: application to real cases". Analytical and Bioanalytical Chemistry. 412 (21): 5125–5145. doi:10.1007/s00216-020-02462-6. hdl:11573/1477635. PMID 32062830. S2CID 211128392.
^ Freni F (2020). "Determination of fentanyl and 19 derivatives in hair: application to an Italian population". Journal of Pharmaceutical and Biomedical Analysis. 189: 113476. doi:10.1016/j.jpba.2020.113476. PMID 32693203. S2CID 220699407.
^ Lanzarotta A (2020). "Identification of opioids and related substances using handheld Raman spectrometers". Journal of Forensic Sciences. 65 (2): 421–427. doi:10.1111/1556-4029.14217. PMID 31643087. S2CID 204849539.
^ Larabi IA (2020). "Development and validation of liquid chromatography-tandem mass spectrometry targeted screening of 16 fentanyl analogs and U-47700 in hair: Application to 137 authentic samples". Drug Testing and Analysis. 12 (9): 1298–1308. doi:10.1002/dta.2868. PMID 32476263. S2CID 219172113.
^ Strayer KE (2018). "A LC-MS/MS-Based Method for the Multiplex Detection of 24 Fentanyl Analogs and Metabolites in Whole Blood at Sub ng mL-1 Concentrations". {{cite journal}}: Cite journal requires |journal= (help)
^ Vaiano F (2021). "Development of a new LC-MS/MS screening method for detection of 120 NPS and 43 drugs in blood". Separations. 8 (11): 221. doi:10.3390/separations8110221.
^ Kern S. "Rapid-field-deployable DART-MS screening technique for 87 opioids and drugs of abuse, including fentanyl and fentanyl analogs". Journal of Regulatory Science. 10 (2).
^ Garneau B (2021). "A comprehensive analytical process, from NPS threat identification to systematic screening: method validation and one-year prevalence study". Forensic Science International. 318: 110595. doi:10.1016/j.forsciint.2020.110595. PMID 33279767. S2CID 227521467.
^ Carelli C (2022). "Old and New Synthetic and Semi-synthetic Opioids Analysis in Hair: A Review". Talanta Open. 100108.

Further reading[edit]

Higashikawa Y, Suzuki S (June 2008). "Studies on 1-(2-phenethyl)-4-(N-propionylanilino)piperidine (fentanyl) and its related compounds. VI. Structure-analgesic activity relationship for fentanyl, methyl-substituted fentanyls and other analogues". Forensic Toxicology. 26 (1): 1–5. doi:10.1007/s11419-007-0039-1. S2CID 22092512.
Alburges ME, Hanson GR, Gibb JW, Sakashita CO, Rollins DE (1992). "Fentanyl receptor assay. II. Utilization of a radioreceptor assay for the analysis of fentanyl analogs in urine". J Anal Toxicol. 16 (1): 36–41. doi:10.1093/jat/16.1.36. PMID 1322477.
Woods J, Medzihradsky F, Smith C, Winger G, Gmerek D (1988). "Evaluation of new compounds for opioid activity: 1987 annual report". NIDA Res. Monogr. 81: 543–90. PMID 3136388.
Aceto M, Bowman E, Harris L, May E (1988). "Dependence studies of new compounds in the rhesus monkey, rat, and mouse, 1987". NIDA Res. Monogr. 81: 485–542. PMID 3136386.
Brine GA, Boldt KG, Huang PT, Sawyer DK, Carroll FI (2009). "Carbon-13 nuclear magnetic resonance spectra of fentanyl analogs". Journal of Heterocyclic Chemistry. 26 (3): 677–686. doi:10.1002/jhet.5570260329.

[1] Strayer KE (2018). "LC-MS/MS-based method for the multiplex detection of 24 fentanyl analogues and metabolites in whole blood at sub ng mL–1 concentrations". ACS Omega. 3 (1): 514–523. doi:10.1021/acsomega.7b01536. PMC 5793031. PMID 29399650.

[2] Mannocchi G (2020). "Development and validation of fast UHPLC-MS/MS screening method for 87 NPS and 32 other drugs of abuse in hair and nails: application to real cases". Analytical and Bioanalytical Chemistry. 412 (21): 5125–5145. doi:10.1007/s00216-020-02462-6. hdl:11573/1477635. PMID 32062830. S2CID 211128392.

[3] Freni F (2020). "Determination of fentanyl and 19 derivatives in hair: application to an Italian population". Journal of Pharmaceutical and Biomedical Analysis. 189: 113476. doi:10.1016/j.jpba.2020.113476. PMID 32693203. S2CID 220699407.

[4] Lanzarotta A (2020). "Identification of opioids and related substances using handheld Raman spectrometers". Journal of Forensic Sciences. 65 (2): 421–427. doi:10.1111/1556-4029.14217. PMID 31643087. S2CID 204849539.

[5] Larabi IA (2020). "Development and validation of liquid chromatography-tandem mass spectrometry targeted screening of 16 fentanyl analogs and U-47700 in hair: Application to 137 authentic samples". Drug Testing and Analysis. 12 (9): 1298–1308. doi:10.1002/dta.2868. PMID 32476263. S2CID 219172113.

[6] Strayer KE (2018). "A LC-MS/MS-Based Method for the Multiplex Detection of 24 Fentanyl Analogs and Metabolites in Whole Blood at Sub ng mL-1 Concentrations". {{cite journal}}: Cite journal requires |journal= (help)

[7] Vaiano F (2021). "Development of a new LC-MS/MS screening method for detection of 120 NPS and 43 drugs in blood". Separations. 8 (11): 221. doi:10.3390/separations8110221.

[8] Kern S. "Rapid-field-deployable DART-MS screening technique for 87 opioids and drugs of abuse, including fentanyl and fentanyl analogs". Journal of Regulatory Science. 10 (2).

[9] Garneau B (2021). "A comprehensive analytical process, from NPS threat identification to systematic screening: method validation and one-year prevalence study". Forensic Science International. 318: 110595. doi:10.1016/j.forsciint.2020.110595. PMID 33279767. S2CID 227521467.

[10] Carelli C (2022). "Old and New Synthetic and Semi-synthetic Opioids Analysis in Hair: A Review". Talanta Open. 100108.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

See also[edit]

References[edit]

Further reading[edit]