Alexander Kabanov (chemist)

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Alexander Kabanov
Born (1962-03-27) 27 March 1962 (age 62)
Moscow, USSR
Alma materMoscow State University
Known forDrug delivery, Nanomedicine
AwardsLenin Komsomol Prize
NSF Career award
RASA George Gamow award
Controlled Release Society Founders award
Scientific career
FieldsChemical, Biomedical
InstitutionsUNC Eshelman School of Pharmacy
Doctoral advisorKarel Martinek
Andrey Levashov

Alexander Viktorovich Kabanov (Russian: Александр Викторович Кабанов; born 27 March 1962 in Moscow, Soviet Union (now Russia)), is a Russian and American chemist, an educator, an entrepreneur, and a researcher in the fields of drug delivery and nanomedicine.

Biography and career[edit]

Kabanov was born in Moscow, USSR on 27 March 1962, in the family of Soviet chemist Viktor A. Kabanov.[1] He graduated from the Faculty of Chemistry of the Moscow State University in 1984, where he also received PhD – Candidate of Chemical Sciences in 1987 and D.Sc. – Doctor of Chemical Sciences in 1990. In 1994 he reallocated to United States to the University of Nebraska Medical Center where he served on a faculty for nearly 18 years[2] before moving to University of North Carolina at Chapel Hill in 2012. He is currently Mescal Swaim Ferguson Distinguished Professor at the UNC Eshelman School of Pharmacy, director of the Center for Nanotechnology in Drug Delivery and the Carolina Institute for Nanomedicine at the University of North Carolina at Chapel Hill.[3]

Kabanov is a highly cited researcher[4] and as of January 2023 has over 47,000 citations with an h-index of 110.[5] He published over 350 scientific papers and holds at least 36 US patents. He co-founded several pharmaceutical companies including Supratek Pharma Inc., SoftKemo, Bendarex and DelAQUA Pharmaceuticals. He trained over 70 graduate students and postdocs, half of whom are women and underrepresented minorities and 16 became faculty.[3]

Kabanov was a founding director of the NIH Center of Biomedical Research Excellence (CoBRE) "Nebraska Center for Nanomedicine" and is the director of the NIH T32 Carolina Cancer Nanotechnology Training Program.[3] He founded the Nanomedicine and Drug Delivery symposium series that has been held annually since 2003.[6] He is the editor-in-chief of the Reviews and Advances in Chemistry.[7] He served a director-at-large of the Controlled Release Society (2019–2022), and is the past President (2018–2020) and the chief executive officer of the Russian American Science Association (RASA).[8]

Contributions to science[edit]

Kabanov made broad impact to pharmaceutical sciences and advanced polymer and colloidal sciences by developing novel methods using nanotechnology for the therapeutic delivery of small drugs, nucleic acids, and proteins. His early work was in the field of enzyme catalysis in surfactant aggregates in organic media,[9] where he developed methods using reverse micelles as nanoscale reactors for modification of proteins, controllable assembly of oligomeric enzymes and tailoring protein-polymer conjugates for bioengineering applications.[10][11] He developed fatty acylated proteins and hydrophobically modified oligonucleotides to impart them ability to interact with lipid membranes and improve transport into a cell and across the blood brain barrier.[12] He and K. Kataoka independently discovered electrostatic driven self-assembly of complexes of polyelectrolyte block copolymers with oppositely charged polyelectrolytes and surfactants ("block ionomer complexes"),[13] and studied basic patterns of nanoparticle formation, morphology, stability, polyelectrolyte interchange and environmental responses in such systems.[14][15][16]

He was among the first to use nanosized complexes of polycations[17] and later, cationic block copolymers for the delivery of nucleic acids into a cell (known today as "polyplexes")[18][19] and developed core-shell polyelectrolyte complexes for the therapeutic drug delivery of polypeptides such as antioxidant enzymes and scavengers of organophosphate poisons.[20][21]

In late the late 1980s Kabanov published seminal work on the use of polymeric micelles as a nanoparticle delivery platform for small drug molecules.[22][23] His work led to the first polymeric micelle drug to enter clinical trials and was instrumental in establishment of polymeric micelles as a clinically approved drug delivery platform.[24][25][26]

Kabanov laboratory published large body of work on pharmacological effects of poloxamer block copolymers, known by the trade name Pluronic.[27][28][29][30] He discovered diverse phenomena induced by these polymers in biology such as inhibition of drug efflux transport systems, hypersensitization of multidrug resistant cancer cells,[31] increased drug permeability across brain microvessel endothelial and intestinal epithelial barriers,[32][30] foreign nucleic acid transfer from macrophages to muscle cells[33] and gene expression in the muscle tissue.[34]

His papers and inventions introduced nanogels,[35][36][37] cross-linked polymeric micelles,[38] and high-capacity poly(2-oxazoline) micelles[39] for the delivery of diverse biological agents. Kabanov and co-workers also reported some of the early work on macrophages[40] and macrophage-derived exosomes[41] for the delivery of therapeutic polypeptides and nucleic acids to the sites of inflammation in the brain to treat neurological diseases.[42]

Awards and honors[edit]

His honors include the Lenin Komsomol Prize (1988), the NSF Career award (1995), the RASA George Gamow award (2017), and the Controlled Release Society Founders award (2022).[43] He was elected a member of Academia Europaea (2013), a corresponding member of the Russian Academy of Sciences (2019),[44] and a fellow of the American Institute for Medical and Biological Engineering (2015),[45] the National Academy of Inventors (2017),[46] the Controlled Release Society (2018), and the American Association for the Advancement of Science (2021).[47]

Public position[edit]

Kabanov has taken public position against the use of chemical weapons[48][49] and in 2021 co-authored a petition signed by nearly a thousand Russian-speaking scientists demanding Russian authorities to end political prosecution of Alexey Navalny and his supporters, investigate his poisoning and turn to international cooperation to confront global threats,[50][51][52] On 24 February 2022, Kabanov signed an open letter of Russian scientists and journalists against the war in Ukraine,[53] and then organized public statements from the Russian-speaking researchers living overseas condemning the Russian aggression in Ukraine and in support of the scholars affected by the war.[54][55][56]

References[edit]

  1. ^ "Victor Aleksandrovich Kabanov (1934–2006)". Polymer Science Series A. 48 (8): 887–889. August 2006. doi:10.1134/S0965545X06080165. ISSN 0965-545X.
  2. ^ Burbach, Karen (7 March 2007). "Meet Distinguished Scientist Alexander 'Sasha' Kabanov, Ph.D., Dr.Sc". Newsroom. Retrieved 2 February 2023.
  3. ^ a b c "Alexander V. Kabanov, Ph.D., Dr.Sci". UNC Eshelman School of Pharmacy. Retrieved 20 January 2023.
  4. ^ "Publons.com". publons.com. Retrieved 20 January 2023.
  5. ^ "Alexander Kabanov". scholar.google.com. Retrieved 20 January 2023.
  6. ^ "NanoDDS2020". nanoDDS. Retrieved 20 January 2023.
  7. ^ "Reviews and Advances in Chemistry". Springer. Retrieved 23 January 2023.
  8. ^ "Russian-American Science Association — Russian-American Science Association" (in Russian). Retrieved 20 January 2023.
  9. ^ Structure and reactivity in reverse micelles. M. P. Pileni. Amsterdam: Elsevier. 1989. ISBN 0-444-88166-2. OCLC 20560416.{{cite book}}: CS1 maint: others (link)
  10. ^ Kabanov, A. V.; Nametkin, S. N.; Evtushenko, G. N.; Chernov, N. N.; Klyachko, N. L.; Levashov, A. V.; Martinek, K. (6 July 1989). "A new strategy for the study of oligomeric enzymes: gamma-glutamyltransferase in reversed micelles of surfactants in organic solvents". Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology. 996 (3): 147–152. doi:10.1016/0167-4838(89)90240-9. ISSN 0006-3002. PMID 2473781.
  11. ^ Kabanov, A. V.; Klyachko, N. L.; Nametkin, S. N.; Merker, S.; Zaroza, A. V.; Bunik, V. I.; Ivanov, M. V.; Levashov, A. V. (1991). "Engineering of functional supramacromolecular complexes of proteins (enzymes) using reversed micelles as matrix microreactors". Protein Engineering. 4 (8): 1009–1017. doi:10.1093/protein/4.8.1009. ISSN 0269-2139. PMID 1726270.
  12. ^ Banks, William A. (April 2016). "From blood–brain barrier to blood–brain interface: new opportunities for CNS drug delivery". Nature Reviews Drug Discovery. 15 (4): 275–292. doi:10.1038/nrd.2015.21. ISSN 1474-1776. PMID 26794270. S2CID 3333779.
  13. ^ Pergushov, Dmitry V.; Müller, Axel H. E.; Schacher, Felix H. (2012). "Micellar interpolyelectrolyte complexes". Chemical Society Reviews. 41 (21): 6888–7701. doi:10.1039/c2cs35135h. ISSN 0306-0012. PMID 22814675.
  14. ^ Read, E.; Lonetti, B.; Gineste, S.; Sutton, A.T.; Di Cola, E.; Castignolles, P.; Gaborieau, M.; Mingotaud, A.-F.; Destarac, M.; Marty, J.-D. (May 2021). "Mechanistic insights into the formation of polyion complex aggregates from cationic thermoresponsive diblock copolymers". Journal of Colloid and Interface Science. 590: 268–276. Bibcode:2021JCIS..590..268R. doi:10.1016/j.jcis.2021.01.028. PMID 33548610. S2CID 231872062.
  15. ^ Gradzielski, Michael (8 November 2022). "Polyelectrolyte–Surfactant Complexes As a Formulation Tool for Drug Delivery". Langmuir. 38 (44): 13330–13343. doi:10.1021/acs.langmuir.2c02166. ISSN 0743-7463. PMID 36278880. S2CID 253097297.
  16. ^ Banda, Srikanth (15 July 2022). "Tumor Biology; Usefulness of Thermosensitive and pH Sensitive Polymeric Nanoparticles for Tumor Targeting: A Review". Journal of Drug Delivery and Therapeutics. 12 (4): 141–153. doi:10.22270/jddt.v12i4.5420. ISSN 2250-1177. S2CID 251030502.
  17. ^ Zhang, Peng; Wagner, Ernst (April 2017). "History of Polymeric Gene Delivery Systems". Topics in Current Chemistry. 375 (2): 26. doi:10.1007/s41061-017-0112-0. ISSN 2365-0869. PMID 28181193. S2CID 36281242.
  18. ^ Self-assembling complexes for gene delivery : from laboratory to clinical trial. Alexander V. Kabanov, Philip L. Felgner, L. W. Seymour. Chichester: Wiley. 1998. ISBN 0-471-97269-X. OCLC 37910787.{{cite book}}: CS1 maint: others (link)
  19. ^ Pereira, Patrícia Alexandra; Serra, Maria Elisa Silva; Serra, Arménio C.; Coelho, Jorge F. J. (September 2022). "Application of vinyl polymer‐based materials as nucleic acids carriers in cancer therapy". WIREs Nanomedicine and Nanobiotechnology. 14 (5): e1820. doi:10.1002/wnan.1820. ISSN 1939-5116. PMID 35637638. S2CID 249234376.
  20. ^ Manickam, Devika S.; Brynskikh, Anna M.; Kopanic, Jennifer L.; Sorgen, Paul L.; Klyachko, Natalia L.; Batrakova, Elena V.; Bronich, Tatiana K.; Kabanov, Alexander V. (28 September 2012). "Well-defined cross-linked antioxidant nanozymes for treatment of ischemic brain injury". Journal of Controlled Release. 162 (3): 636–645. doi:10.1016/j.jconrel.2012.07.044. ISSN 1873-4995. PMC 3597468. PMID 22902590.
  21. ^ Osborne, Hannah (4 April 2017). "Scientists create biological shield to protect against chemical weapons – including sarin gas". International Business Times UK. Retrieved 30 January 2023.
  22. ^ Kabanov, A. V.; Chekhonin, V. P.; Alakhov VYu, null; Batrakova, E. V.; Lebedev, A. S.; Melik-Nubarov, N. S.; Arzhakov, S. A.; Levashov, A. V.; Morozov, G. V.; Severin, E. S. (4 December 1989). "The neuroleptic activity of haloperidol increases after its solubilization in surfactant micelles. Micelles as microcontainers for drug targeting". FEBS Letters. 258 (2): 343–345. doi:10.1016/0014-5793(89)81689-8. ISSN 0014-5793. PMID 2599097. S2CID 35126702.
  23. ^ Allen, Christine; Maysinger, Dusica; Eisenberg, Adi (1 November 1999). "Nano-engineering block copolymer aggregates for drug delivery". Colloids and Surfaces B: Biointerfaces. 16 (1): 3–27. doi:10.1016/S0927-7765(99)00058-2. ISSN 0927-7765.
  24. ^ Hwang, Duhyeong; Ramsey, Jacob D.; Kabanov, Alexander V. (2020). "Polymeric micelles for the delivery of poorly soluble drugs: From nanoformulation to clinical approval". Advanced Drug Delivery Reviews. 156: 80–118. doi:10.1016/j.addr.2020.09.009. ISSN 1872-8294. PMC 8173698. PMID 32980449.
  25. ^ Pitto-Barry, Anaïs; Barry, Nicolas P. E. (24 March 2014). "Pluronic® block-copolymers in medicine: from chemical and biological versatility to rationalisation and clinical advances". Polym. Chem. 5 (10): 3291–3297. doi:10.1039/C4PY00039K. hdl:10454/11223. ISSN 1759-9954.
  26. ^ Bose, Anamika; Roy Burman, Debanwita; Sikdar, Bismayan; Patra, Prasun (February 2021). "Nanomicelles: Types, properties and applications in drug delivery". IET Nanobiotechnology. 15 (1): 19–27. doi:10.1049/nbt2.12018. ISSN 1751-8741. PMC 8675821. PMID 34694727.
  27. ^ Batrakova, Elena V.; Kabanov, Alexander V. (10 September 2008). "Pluronic block copolymers: evolution of drug delivery concept from inert nanocarriers to biological response modifiers". Journal of Controlled Release. 130 (2): 98–106. doi:10.1016/j.jconrel.2008.04.013. ISSN 1873-4995. PMC 2678942. PMID 18534704.
  28. ^ Li, Jing; Yu, Fei; Chen, Yi; Oupický, David (December 2015). "Polymeric drugs: Advances in the development of pharmacologically active polymers". Journal of Controlled Release. 219: 369–382. doi:10.1016/j.jconrel.2015.09.043. PMC 4656093. PMID 26410809.
  29. ^ de Castro, Karine Cappuccio; Coco, Julia Cedran; dos Santos, Érica Mendes; Ataide, Janaína Artem; Martinez, Renata Miliani; do Nascimento, Mônica Helena Monteiro; Prata, João; da Fonte, Pedro Ricardo Martins Lopes; Severino, Patrícia; Mazzola, Priscila Gava; Baby, André Rolim; Souto, Eliana Barbosa; de Araujo, Daniele Ribeiro; Lopes, André Moreni (1 January 2023). "Pluronic® triblock copolymer-based nanoformulations for cancer therapy: A 10-year overview". Journal of Controlled Release. 353: 802–822. doi:10.1016/j.jconrel.2022.12.017. ISSN 0168-3659. PMID 36521691. S2CID 254851024.
  30. ^ a b Rodriguez‐Otormin, Fernanda; Duro‐Castano, Aroa; Conejos‐Sánchez, Inmaculada; Vicent, María J. (January 2019). "Envisioning the future of polymer therapeutics for brain disorders". WIREs Nanomedicine and Nanobiotechnology. 11 (1): e1532. doi:10.1002/wnan.1532. ISSN 1939-5116. PMID 29900681. S2CID 49190092.
  31. ^ Alakhov VYu, null; Moskaleva EYu, null; Batrakova, E. V.; Kabanov, A. V. (1996). "Hypersensitization of multidrug resistant human ovarian carcinoma cells by pluronic P85 block copolymer". Bioconjugate Chemistry. 7 (2): 209–216. doi:10.1021/bc950093n. ISSN 1043-1802. PMID 8983343.
  32. ^ Batrakova, E. V.; Han, H. Y.; Miller, D. W.; Kabanov, A. V. (1998). "Effects of pluronic P85 unimers and micelles on drug permeability in polarized BBMEC and Caco-2 cells". Pharmaceutical Research. 15 (10): 1525–1532. doi:10.1023/a:1011942814300. ISSN 0724-8741. PMID 9794493. S2CID 21477541.
  33. ^ Mahajan, Vivek; Gaymalov, Zagit; Alakhova, Daria; Gupta, Richa; Zucker, Irving H.; Kabanov, Alexander V. (2016). "Horizontal gene transfer from macrophages to ischemic muscles upon delivery of naked DNA with Pluronic block copolymers". Biomaterials. 75: 58–70. doi:10.1016/j.biomaterials.2015.10.002. ISSN 1878-5905. PMC 4644506. PMID 26480472.
  34. ^ Lemieux, P.; Guérin, N.; Paradis, G.; Proulx, R.; Chistyakova, L.; Kabanov, A.; Alakhov, V. (2000). "A combination of poloxamers increases gene expression of plasmid DNA in skeletal muscle". Gene Therapy. 7 (11): 986–991. doi:10.1038/sj.gt.3301189. ISSN 0969-7128. PMID 10849559. S2CID 23373574.
  35. ^ Vinogradov, Serguei; Batrakova, Elena; Kabanov, Alexander (1 November 1999). "Poly(ethylene glycol)–polyethyleneimine NanoGel™ particles: novel drug delivery systems for antisense oligonucleotides". Colloids and Surfaces B: Biointerfaces. 16 (1): 291–304. doi:10.1016/S0927-7765(99)00080-6. ISSN 0927-7765.
  36. ^ Pinelli, Filippo; Saadati, Marjan; Zare, Ehsan Nazarzadeh; Makvandi, Pooyan; Masi, Maurizio; Sacchetti, Alessandro; Rossi, Filippo (26 January 2022). "A perspective on the applications of functionalized nanogels: promises and challenges". International Materials Reviews: 1–25. doi:10.1080/09506608.2022.2026864. hdl:11311/1205555. ISSN 0950-6608. S2CID 246344697.
  37. ^ Zoratto, N.; Montanari, E.; Viola, M.; Wang, J.; Coviello, T.; Di Meo, C.; Matricardi, P. (15 August 2021). "Strategies to load therapeutics into polysaccharide-based nanogels with a focus on microfluidics: A review". Carbohydrate Polymers. 266: 118119. doi:10.1016/j.carbpol.2021.118119. hdl:20.500.11850/484286. ISSN 0144-8617. PMID 34044935. S2CID 235231653.
  38. ^ Bronich, Tatiana K.; Keifer, Paul A.; Shlyakhtenko, Luda S.; Kabanov, Alexander V. (15 June 2005). "Polymer micelle with cross-linked ionic core". Journal of the American Chemical Society. 127 (23): 8236–8237. doi:10.1021/ja043042m. ISSN 0002-7863. PMID 15941228.
  39. ^ Luxenhofer, Robert; Schulz, Anita; Roques, Caroline; Li, Shu; Bronich, Tatiana K.; Batrakova, Elena V.; Jordan, Rainer; Kabanov, Alexander V. 6 (2010). "Doubly amphiphilic poly(2-oxazoline)s as high-capacity delivery systems for hydrophobic drugs". Biomaterials. 31 (18): 4972–4979. doi:10.1016/j.biomaterials.2010.02.057. ISSN 1878-5905. PMC 2884201. PMID 20346493.{{cite journal}}: CS1 maint: numeric names: authors list (link)
  40. ^ Batrakova, Elena V.; Li, Shu; Reynolds, Ashley D.; Mosley, R. Lee; Bronich, Tatiana K.; Kabanov, Alexander V.; Gendelman, Howard E. (2007). "A macrophage-nanozyme delivery system for Parkinson's disease". Bioconjugate Chemistry. 18 (5): 1498–1506. doi:10.1021/bc700184b. ISSN 1043-1802. PMC 2677172. PMID 17760417.
  41. ^ Haney, Matthew J.; Klyachko, Natalia L.; Zhao, Yuling; Gupta, Richa; Plotnikova, Evgeniya G.; He, Zhijian; Patel, Tejash; Piroyan, Aleksandr; Sokolsky, Marina; Kabanov, Alexander V.; Batrakova, Elena V. (10 June 2015). "Exosomes as drug delivery vehicles for Parkinson's disease therapy". Journal of Controlled Release. 207: 18–30. doi:10.1016/j.jconrel.2015.03.033. ISSN 1873-4995. PMC 4430381. PMID 25836593.
  42. ^ neurons, Scientists at UNC have developed methods to restore; disease, reduce the progression of Parkinson’s. "UNC researchers close to Parkinson's treatment". The Daily Tar Heel. Retrieved 30 January 2023.
  43. ^ "Controlled Release Society 2022 Awards announced - Awards - Journal of Controlled Release - Journal - Elsevier". www.journals.elsevier.com. Retrieved 28 January 2023.
  44. ^ Jennings, Brittany (27 November 2019). "Professor becomes first Russian-American scientist elected to Russian Academy of Sciences". UNC Eshelman School of Pharmacy. Retrieved 28 January 2023.
  45. ^ "Alexander V. Kabanov, Ph.D., Dr.Sc. COF-1817 - AIMBE". Retrieved 30 January 2023.
  46. ^ Mendenhall, Grayson (12 December 2017). "Kabanov Elected to National Academy of Inventors". UNC Eshelman School of Pharmacy. Retrieved 30 January 2023.
  47. ^ Jared, H. (28 January 2022). "AAAS honors 4 faculty as fellows". The Well. Retrieved 28 January 2023.
  48. ^ Willingham, Emily. "Gel Packed with Chemical "Scavengers" Protects against Sarin Gas". Scientific American. Retrieved 28 January 2023.
  49. ^ "Scientists petition to end political persecution in Russia". ABC Radio National. 1 May 2021. Retrieved 30 January 2023.
  50. ^ Kabanov, Alexander; Krasnok, Alex; Seletskiy, Denis (2021). "Russia: scientists petition to end political persecution". Nature. 591 (7849): 202. Bibcode:2021Natur.591..202K. doi:10.1038/d41586-021-00594-y. ISSN 1476-4687. PMID 33664514. S2CID 232124322.
  51. ^ "'The situation could well lead to a catastrophe' More than 100 scientists and scholars, including Nobel laureates, sign open letter demanding that Russia stop persecuting activists and turn instead to international cooperation". Meduza. Retrieved 20 January 2023.
  52. ^ "The legacy of Andrei Sakharov and the state of Russian science today". ABC Radio National. 12 June 2021. Retrieved 28 January 2023.
  53. ^ "Открытое письмо российских ученых и научных журналистов против войны с Украиной – Т-инвариант / T-invariant" (in Russian). Retrieved 20 January 2023.
  54. ^ Gaind, Nisha; Else, Holly (2022). "Global research community condemns Russian invasion of Ukraine". Nature. 603 (7900): 209–210. Bibcode:2022Natur.603..209G. doi:10.1038/d41586-022-00601-w. ISSN 1476-4687. PMID 35233085. S2CID 247189994.
  55. ^ "Protect Scholars! - Diaspora against the war". sites.google.com. Retrieved 20 January 2023.
  56. ^ "Protect Scholars!". sites.google.com. Retrieved 20 January 2023.
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