File:Toxins-09-00300-g001.gif

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Summary

Description
English: CyaA is a 1706 residue-long polypeptide that consists of an N-terminal AC enzyme domain (~400 residues) and a C-terminal Hly moiety (~1300 residues) that are linked together with a ~100 residue-long segment (residues 400 to 500). The Hly portion of CyaA itself harbors several functional subdomains: (i) a hydrophobic pore-forming domain (residues 500 to 700); (ii) an activation domain (residues 800 and 1000), where the posttranslational acylation at two lysine residues (K860 and K983) occurs; (iii) a typical calcium-binding RTX domain with the nonapeptide repeats binding calcium ions and with the CD11b/CD18-binding segment (residues 1166–1287); and (iv) a C-terminal secretion signal.
Date
Source https://pubmed.ncbi.nlm.nih.gov/28946636/#&gid=article-figures&pid=figure-1-uid-0
Author Jakub Novak, Ondrej Cerny, Adriana Osickova, Irena Linhartova, Jiri Masin, Ladislav Bumba, Peter Sebo, Radim Osicka

Licensing

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attribution
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Captions

Schematic representation of CyaA.

Items portrayed in this file

depicts

24 September 2017

File history

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Date/TimeThumbnailDimensionsUserComment
current17:51, 30 June 2021Thumbnail for version as of 17:51, 30 June 2021200 × 54 (7 KB)KyrosFilUploaded a work by Jakub Novak, Ondrej Cerny, Adriana Osickova, Irena Linhartova, Jiri Masin, Ladislav Bumba, Peter Sebo, Radim Osicka from https://pubmed.ncbi.nlm.nih.gov/28946636/#&gid=article-figures&pid=figure-1-uid-0 with UploadWizard
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