File:Histopathology of pilomatricoma, high magnification, annotated.jpg

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Histopathology of pilomatricoma, high magnification, H&E stain, showing the characteristic components:
Stroma of fibrovascular connective tissue surrounding irregularly shaped, lobulated islands containing basaloid cells (being darkly stained, round or elongated, with indistinct cell borders and minimal cytoplasm, with nuclei being round to ovoid, deeply basophilic and generally prominent nucleoli), which abruptly or (like here) gradually transitions into ghost cells (having abundant, pale, eosinophilic cytoplasm, well defined cell borders and a central clear area, but only only faint traces of nuclear material), which in turn may transition into keratinaceous to amorphous necrosis.[1]

Reference

  1. ↑ Punnya V Angadi (2009-06-01). Skin: Pilomatricoma. Atlas of Genetics and Cytogenetics in Oncology and Haematology.

Gallery of the same case

  • Low magnification
    Low magnification
  • High magnification
    High magnification
  • High magnification, annotated
    High magnification, annotated
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Author
Mikael Häggström, M.D. Author info
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Mikael Häggström, M.D.
Consent note: Consent from the patient or patient's relatives is regarded as redundant, because of absence of identifiable features (List of HIPAA identifiers) in the media and case information (See also HIPAA case reports guidance).

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Histopathology of pilomatricoma, high magnification, H&E stain

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