File:Histopathology of a high-grade serous carcinoma arising from a serous borderline tumor, with p53 stain.jpg
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Summary
| Description |
English: A high-grade serous carcinoma arising from a borderline serous tumor. A. Low-magnification view shows a focal high-grade serous carcinoma developing from the papillae (square) in a background of a typical serous borderline tumor. B. Higher magnification demonstrates enlarged and atypical high-grade serous carcinoma cells that organize in a papillary architecture. C and D. Immunohistochemistry of p53 shows that high-grade serous carcinoma cells are diffusely positive for p53, a pattern consistent with a missense TP53 mutation while the adjacent epithelial cells from the background serous borderline tumor are only focally and weakly positive, a pattern consistent with a wild-type TP53 sequence. |
| Date | |
| Source |
(2015). "Adenocarcinoma of Mullerian origin: review of pathogenesis, molecular biology, and emerging treatment paradigms". Gynecologic Oncology Research and Practice 2 (1). DOI:10.1186/s40661-015-0008-z. ISSN 2053-6844. - "Figure 3- available via license: Creative Commons Attribution 4.0 International" |
| Author | Cobb, Lauren Patterson; Gaillard, Stephanie; Wang, Yihong; Shih, Ie-Ming; Secord, Angeles Alvarez |
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 10:19, 17 March 2020 | | 1,153 × 885 (471 KB) | Mikael Häggström | Uploaded a work by Cobb, Lauren Patterson; Gaillard, Stephanie; Wang, Yihong; Shih, Ie-Ming; Secord, Angeles Alvarez from {{cite journal|last1=Cobb|first1=Lauren Patterson|last2=Gaillard|first2=Stephanie|last3=Wang|first3=Yihong|last4=Shih|first4=Ie-Ming|last5=Secord|first5=Angeles Alvarez|title=Adenocarcinoma of Mullerian origin: review of pathogenesis, molecular biology, and emerging treatment paradigms|journal=Gynecologic Oncology Research and Practice|volume=2|issue=1|year=2015|issn=2053-... |
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