English: Levels of estradiol and estrone with once daily application of 1.25 g of a transdermal estradiol gel containing 0.06% or 0.75 mg estradiol (brand name EstroGel) after 14 days of continuous treatment in postmenopausal women. The gel was applied to the posterior surface of one arm from wrist to shoulder. The following description is from the source of the values:

EstroGel 1.25 g (containing 0.75 mg of estradiol) was administered to 24 postmenopausal women once daily on the posterior surface of 1 arm from wrist to shoulder for 14 consecutive days. Mean maximal serum concentrations of estradiol and estrone on Day 14 were 46.4 pg/mL and 64.2 pg/mL, respectively. The time-averaged serum estradiol and estrone concentrations over the 24-hour dose interval after administration of 1.25 g EstroGel on Day 14 are 28.3 pg/mL and 48.6 pg/mL, respectively. Mean concentration-time profiles for unadjusted estradiol and estrone on Day 14 are shown in Figure 1.

Source of the values (EstroGel FDA label): [1]