File:Castleman disease - high mag.jpg

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Summary

Description
English: High magnification micrograph of Castleman disease, hyaline vascular variant, also known as angiofollicular lymph node hyperplasia and giant lymph node hyperplasia. H&E stain.

Features:

  1. Pale concentric (expanded) mantle zone (lymphocytes).
    • "Regressed follicles" - germinal center (pale area) is small.
  2. "Lollipops":
    • Germinal centers fed by prominent (radially penetrating sclerotic) vessels; lollipop-like appearance.
  3. Two germinal centers in one follicle.
  4. Hyaline material (pink acellular stuff on H&E stained sections) in germinal center.
  5. Sinuses effaced (lost).

Related images

  • Low mag.
    Low mag.
  • Intermed. mag.
    Intermed. mag.
  • Very high mag.
    Very high mag.
Source Own work
Author Nephron

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current02:54, 12 August 2010Thumbnail for version as of 02:54, 12 August 20102,848 × 4,272 (6.57 MB)Nephron{{Information |Description={{en|1=High magnification micrograph of '''Castleman disease, hyaline vascular variant''', also known as '''angiofollicular lymph node hyperplasia''' and '''giant lymph node hyperplasia''

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