WNT8B

From Wikipedia, the free encyclopedia
WNT8B
Identifiers
AliasesWNT8B, Wnt family member 8B
External IDsOMIM: 601396 MGI: 109485 HomoloGene: 2550 GeneCards: WNT8B
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003393

NM_011720

RefSeq (protein)

NP_003384

n/a

Location (UCSC)Chr 10: 100.46 – 100.48 MbChr 19: 44.48 – 44.5 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Protein Wnt-8b is a protein that in humans is encoded by the WNT8B gene.[5][6]

The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis.

This gene is a member of the WNT gene family. It encodes a protein showing 95%, 86%, and 71% amino acid identity to the mouse, zebrafish and Xenopus Wnt8B proteins, respectively. The expression patterns of the human and mouse genes appear identical and are restricted to the developing brain. The chromosomal location of this gene to 10q24 suggests it as a candidate gene for partial epilepsy.[6]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000075290 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000036961 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Lako M, Strachan T, Curtis AR, Lindsay S (Sep 1996). "Isolation and characterization of WNT8B, a novel human Wnt gene that maps to 10q24". Genomics. 35 (2): 386–8. doi:10.1006/geno.1996.0374. PMID 8661156.
  6. ^ a b "Entrez Gene: WNT8B wingless-type MMTV integration site family, member 8B".

Further reading[edit]