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Protein-coding gene in the species Homo sapiens
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform is an enzyme that in humans is encoded by the PPP2R5E gene .[5] [6]
Function [ edit ] The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes an epsilon isoform of the regulatory subunit B56 subfamily.[6]
Interactions [ edit ] PPP2R5E has been shown to interact with PPP2R1B [7] PPP2CA .[7] [8]
References [ edit ]
^ a b c GRCh38: Ensembl release 89: ENSG00000154001 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021051 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ McCright B, Virshup DM (Nov 1995). "Identification of a new family of protein phosphatase 2A regulatory subunits" . The Journal of Biological Chemistry . 270 (44): 26123–8. doi :10.1074/jbc.270.44.26123 PMID 7592815 . ^ a b "Entrez Gene: PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform" .^ a b McCright B, Rivers AM, Audlin S, Virshup DM (Sep 1996). "The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm" . The Journal of Biological Chemistry . 271 (36): 22081–9. doi :10.1074/jbc.271.36.22081 PMID 8703017 . ^ Goudreault M, D'Ambrosio LM, Kean MJ, Mullin MJ, Larsen BG, Sanchez A, Chaudhry S, Chen GI, Sicheri F, Nesvizhskii AI, Aebersold R, Raught B, Gingras AC (Jan 2009). "A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein" . Molecular & Cellular Proteomics . 8 (1): 157–71. doi :10.1074/mcp.M800266-MCP200 PMC 2621004 PMID 18782753 .
Further reading [ edit ]
Le Rouzic E, Benichou S (2006). "The Vpr protein from HIV-1: distinct roles along the viral life cycle" . Retrovirology . 2 : 11. doi :10.1186/1742-4690-2-11 PMC 554975 PMID 15725353 . Zhao RY, Elder RT (Mar 2005). "Viral infections and cell cycle G2/M regulation" . Cell Research . 15 (3): 143–9. doi :10.1038/sj.cr.7290279 PMID 15780175 . Zhao RY, Bukrinsky M, Elder RT (Apr 2005). "HIV-1 viral protein R (Vpr) & host cellular responses". The Indian Journal of Medical Research . 121 (4): 270–86. PMID 15817944 . Zolnierowicz S, Van Hoof C, Andjelković N, Cron P, Stevens I, Merlevede W, Goris J, Hemmings BA (Jul 1996). "The variable subunit associated with protein phosphatase 2A0 defines a novel multimember family of regulatory subunits" . The Biochemical Journal . 317 (Pt 1): 187–94. doi :10.1042/bj3170187 . PMC 1217462 PMID 8694763 . McCright B, Rivers AM, Audlin S, Virshup DM (Sep 1996). "The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm" . The Journal of Biological Chemistry . 271 (36): 22081–9. doi :10.1074/jbc.271.36.22081 PMID 8703017 . McCright B, Brothman AR, Virshup DM (Aug 1996). "Assignment of human protein phosphatase 2A regulatory subunit genes b56alpha, b56beta, b56gamma, b56delta, and b56epsilon (PPP2R5A-PPP2R5E), highly expressed in muscle and brain, to chromosome regions 1q41, 11q12, 3p21, 6p21.1, and 7p11.2 --> p12". Genomics . 36 (1): 168–70. doi :10.1006/geno.1996.0438 . PMID 8812429 . Tung HY, De Rocquigny H, Zhao LJ, Cayla X, Roques BP, Ozon R (Jan 1997). "Direct activation of protein phosphatase-2A0 by HIV-1 encoded protein complex NCp7:vpr" . FEBS Letters . 401 (2–3): 197–201. doi :10.1016/S0014-5793(96)01470-6 PMID 9013886 . Ruediger R, Brewis N, Ohst K, Walter G (Nov 1997). "Increasing the ratio of PP2A core enzyme to holoenzyme inhibits Tat-stimulated HIV-1 transcription and virus production" . Virology . 238 (2): 432–43. doi :10.1006/viro.1997.8873 PMID 9400615 . Elder RT, Yu M, Chen M, Zhu X, Yanagida M, Zhao Y (Sep 2001). "HIV-1 Vpr induces cell cycle G2 arrest in fission yeast (Schizosaccharomyces pombe) through a pathway involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25" . Virology . 287 (2): 359–70. doi :10.1006/viro.2001.1007 PMID 11531413 . Hrimech M, Yao XJ, Branton PE, Cohen EA (Jul 2002). "Human immunodeficiency virus type 1 Vpr-mediated G(2) cell cycle arrest: Vpr interferes with cell cycle signaling cascades by interacting with the B subunit of serine/threonine protein phosphatase 2A" . The EMBO Journal . 21 (14): 3918. doi :10.1093/emboj/cdf420 . PMC 126131 PMID 12110603 . Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (Jul 2004). "Functional proteomics mapping of a human signaling pathway" . Genome Research . 14 (7): 1324–32. doi :10.1101/gr.2334104 . PMC 442148 PMID 15231748 . Dozier C, Bonyadi M, Baricault L, Tonasso L, Darbon JM (Sep 2004). "Regulation of Chk2 phosphorylation by interaction with protein phosphatase 2A via its B' regulatory subunit" . Biology of the Cell . 96 (7): 509–17. doi :10.1016/j.biolcel.2004.04.010 PMID 15380617 . Ammosova T, Washington K, Debebe Z, Brady J, Nekhai S (2006). "Dephosphorylation of CDK9 by protein phosphatase 2A and protein phosphatase-1 in Tat-activated HIV-1 transcription" . Retrovirology . 2 : 47. doi :10.1186/1742-4690-2-47 PMC 1187922 PMID 16048649 .
