Integrin beta 4

ITGB4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1QG3, 2YRZ, 3F7P, 3F7Q, 3F7R, 3FQ4, 3FSO, 3H6A, 4Q58, 4WTW, 4WTX
Identifiers
Aliases	ITGB4, CD104, GP150, integrin subunit beta 4, JEB5A, JEB5B
External IDs	OMIM: 147557 MGI: 96613 HomoloGene: 179 GeneCards: ITGB4
Gene location (Human)
Chr.	Chromosome 17 (human)
End	75,757,818 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	115,899,238 bp
RNA expression pattern
	Top expressed in
	tibial nerve; ; minor salivary glands; ; sural nerve; ; skin of abdomen; ; right uterine tube; ; body of stomach; ; gastric mucosa; ; spinal ganglia; ; spleen; ; parotid gland;
	Top expressed in
	corneal stroma; ; lip; ; sciatic nerve; ; molar; ; esophagus; ; pyloric antrum; ; large intestine; ; colon; ; mucous cell of stomach; ; left colon;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; G protein-coupled receptor binding; neuregulin binding; insulin-like growth factor I binding; integrin binding;
Cellular component	integral component of membrane; membrane; receptor complex; plasma membrane; hemidesmosome; cell surface; integrin complex; cell junction; cell leading edge; extracellular exosome; nucleus; focal adhesion;
Biological process	hemidesmosome assembly; renal system development; nail development; cell motility; extracellular matrix organization; autophagy; cell communication; cell adhesion; response to wounding; mesodermal cell differentiation; integrin-mediated signaling pathway; digestive tract development; cell-matrix adhesion; skin development; amelogenesis; cell migration; cell adhesion mediated by integrin;
	Sources:Amigo / QuickGO
Orthologs
	3691
	192897
	ENSG00000132470
	ENSMUSG00000020758
	P16144
	A2A863
	NM_000213; NM_001005619; NM_001005731; NM_001321123
	NM_001005608; NM_133663
	NP_000204; NP_001005619; NP_001005731; NP_001308052
	NP_001005608; NP_598424; NP_001392055; NP_001392056
	Wikidata
View/Edit Human	View/Edit Mouse

Integrin, beta 4 (ITGB4) also known as CD104 (Cluster of Differentiation 104), is a human gene.^[5]

Function[edit]

Integrins are heterodimers composed of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.^[5]

Interactions[edit]

ITGB4 has been shown to interact with Collagen, type XVII, alpha 1,^[6]^[7] EIF6^[8] and Erbin.^[9]

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000132470 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020758 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: ITGB4 integrin, beta 4".
^ Aho S, Uitto J (Feb 1998). "Direct interaction between the intracellular domains of bullous pemphigoid antigen 2 (BP180) and beta 4 integrin, hemidesmosomal components of basal keratinocytes". Biochemical and Biophysical Research Communications. 243 (3): 694–9. doi:10.1006/bbrc.1998.8162. PMID 9500991.
^ Schaapveld RQ, Borradori L, Geerts D, van Leusden MR, Kuikman I, Nievers MG, Niessen CM, Steenbergen RD, Snijders PJ, Sonnenberg A (Jul 1998). "Hemidesmosome formation is initiated by the beta4 integrin subunit, requires complex formation of beta4 and HD1/plectin, and involves a direct interaction between beta4 and the bullous pemphigoid antigen 180". The Journal of Cell Biology. 142 (1): 271–84. doi:10.1083/jcb.142.1.271. PMC 2133016. PMID 9660880.
^ Biffo S, Sanvito F, Costa S, Preve L, Pignatelli R, Spinardi L, Marchisio PC (Nov 1997). "Isolation of a novel beta4 integrin-binding protein (p27(BBP)) highly expressed in epithelial cells". The Journal of Biological Chemistry. 272 (48): 30314–21. doi:10.1074/jbc.272.48.30314. PMID 9374518.
^ Favre B, Fontao L, Koster J, Shafaatian R, Jaunin F, Saurat JH, Sonnenberg A, Borradori L (Aug 2001). "The hemidesmosomal protein bullous pemphigoid antigen 1 and the integrin beta 4 subunit bind to ERBIN. Molecular cloning of multiple alternative splice variants of ERBIN and analysis of their tissue expression". The Journal of Biological Chemistry. 276 (35): 32427–36. doi:10.1074/jbc.M011005200. PMID 11375975.

Further reading[edit]

Lipscomb EA, Mercurio AM (Sep 2005). "Mobilization and activation of a signaling competent alpha6beta4integrin underlies its contribution to carcinoma progression". Cancer and Metastasis Reviews. 24 (3): 413–23. doi:10.1007/s10555-005-5133-4. PMID 16258729. S2CID 26150860.
Sonnenberg A, Linders CJ, Modderman PW, Damsky CH, Aumailley M, Timpl R (Jun 1990). "Integrin recognition of different cell-binding fragments of laminin (P1, E3, E8) and evidence that alpha 6 beta 1 but not alpha 6 beta 4 functions as a major receptor for fragment E8". The Journal of Cell Biology. 110 (6): 2145–55. doi:10.1083/jcb.110.6.2145. PMC 2116116. PMID 1693624.
Tamura RN, Rozzo C, Starr L, Chambers J, Reichardt LF, Cooper HM, Quaranta V (Oct 1990). "Epithelial integrin alpha 6 beta 4: complete primary structure of alpha 6 and variant forms of beta 4". The Journal of Cell Biology. 111 (4): 1593–604. doi:10.1083/jcb.111.4.1593. PMC 2116232. PMID 1976638.
Hogervorst F, Kuikman I, van Kessel AG, Sonnenberg A (Jul 1991). "Molecular cloning of the human alpha 6 integrin subunit. Alternative splicing of alpha 6 mRNA and chromosomal localization of the alpha 6 and beta 4 genes". European Journal of Biochemistry. 199 (2): 425–33. doi:10.1111/j.1432-1033.1991.tb16140.x. PMID 2070796.
Vogel BE, Tarone G, Giancotti FG, Gailit J, Ruoslahti E (Apr 1990). "A novel fibronectin receptor with an unexpected subunit composition (alpha v beta 1)". The Journal of Biological Chemistry. 265 (11): 5934–7. doi:10.1016/S0021-9258(19)39268-3. PMID 2138612.
Suzuki S, Naitoh Y (Mar 1990). "Amino acid sequence of a novel integrin beta 4 subunit and primary expression of the mRNA in epithelial cells". The EMBO Journal. 9 (3): 757–63. doi:10.1002/j.1460-2075.1990.tb08170.x. PMC 551732. PMID 2311577.
Hogervorst F, Kuikman I, von dem Borne AE, Sonnenberg A (Mar 1990). "Cloning and sequence analysis of beta-4 cDNA: an integrin subunit that contains a unique 118 kd cytoplasmic domain". The EMBO Journal. 9 (3): 765–70. doi:10.1002/j.1460-2075.1990.tb08171.x. PMC 551734. PMID 2311578.
Kajiji S, Tamura RN, Quaranta V (Mar 1989). "A novel integrin (alpha E beta 4) from human epithelial cells suggests a fourth family of integrin adhesion receptors". The EMBO Journal. 8 (3): 673–80. doi:10.1002/j.1460-2075.1989.tb03425.x. PMC 400860. PMID 2542022.
Hemler ME, Crouse C, Sonnenberg A (Apr 1989). "Association of the VLA alpha 6 subunit with a novel protein. A possible alternative to the common VLA beta 1 subunit on certain cell lines". The Journal of Biological Chemistry. 264 (11): 6529–35. doi:10.1016/S0021-9258(18)83380-4. PMID 2649503.
Vidal F, Aberdam D, Miquel C, Christiano AM, Pulkkinen L, Uitto J, Ortonne JP, Meneguzzi G (Jun 1995). "Integrin beta 4 mutations associated with junctional epidermolysis bullosa with pyloric atresia". Nature Genetics. 10 (2): 229–34. doi:10.1038/ng0695-229. PMID 7545057. S2CID 24894174.
Mainiero F, Pepe A, Wary KK, Spinardi L, Mohammadi M, Schlessinger J, Giancotti FG (Sep 1995). "Signal transduction by the alpha 6 beta 4 integrin: distinct beta 4 subunit sites mediate recruitment of Shc/Grb2 and association with the cytoskeleton of hemidesmosomes". The EMBO Journal. 14 (18): 4470–81. doi:10.1002/j.1460-2075.1995.tb00126.x. PMC 394539. PMID 7556090.
Clarke AS, Lotz MM, Mercurio AM (Apr 1994). "A novel structural variant of the human beta 4 integrin cDNA". Cell Adhesion and Communication. 2 (1): 1–6. doi:10.3109/15419069409014197. PMID 7982032.
Weeks BS, Desai K, Loewenstein PM, Klotman ME, Klotman PE, Green M, Kleinman HK (Mar 1993). "Identification of a novel cell attachment domain in the HIV-1 Tat protein and its 90-kDa cell surface binding protein". The Journal of Biological Chemistry. 268 (7): 5279–84. doi:10.1016/S0021-9258(18)53530-4. PMID 8444901.
Iacovacci S, Gagnoux-Palacios L, Zambruno G, Meneguzzi G, D'Alessio M (Jun 1997). "Genomic organization of the human integrin beta4 gene". Mammalian Genome. 8 (6): 448–50. doi:10.1007/s003359900467. PMID 9166594. S2CID 41037975.
Mainiero F, Murgia C, Wary KK, Curatola AM, Pepe A, Blumemberg M, Westwick JK, Der CJ, Giancotti FG (May 1997). "The coupling of alpha6beta4 integrin to Ras-MAP kinase pathways mediated by Shc controls keratinocyte proliferation". The EMBO Journal. 16 (9): 2365–75. doi:10.1093/emboj/16.9.2365. PMC 1169837. PMID 9171350.
Pulkkinen L, Kurtz K, Xu Y, Bruckner-Tuderman L, Uitto J (Jun 1997). "Genomic organization of the integrin beta 4 gene (ITGB4): a homozygous splice-site mutation in a patient with junctional epidermolysis bullosa associated with pyloric atresia". Laboratory Investigation. 76 (6): 823–33. PMID 9194858.
van Leusden MR, Kuikman I, Sonnenberg A (Jun 1997). "The unique cytoplasmic domain of the human integrin variant beta4E is produced by partial retention of intronic sequences". Biochemical and Biophysical Research Communications. 235 (3): 826–30. doi:10.1006/bbrc.1997.6892. PMID 9207246.
von Bredow DC, Nagle RB, Bowden GT, Cress AE (Oct 1997). "Cleavage of beta 4 integrin by matrilysin". Experimental Cell Research. 236 (1): 341–5. doi:10.1006/excr.1997.3711. PMID 9344615.
Biffo S, Sanvito F, Costa S, Preve L, Pignatelli R, Spinardi L, Marchisio PC (Nov 1997). "Isolation of a novel beta4 integrin-binding protein (p27(BBP)) highly expressed in epithelial cells". The Journal of Biological Chemistry. 272 (48): 30314–21. doi:10.1074/jbc.272.48.30314. PMID 9374518.
Pulkkinen L, Kim DU, Uitto J (Jan 1998). "Epidermolysis bullosa with pyloric atresia: novel mutations in the beta4 integrin gene (ITGB4)". The American Journal of Pathology. 152 (1): 157–66. PMC 1858138. PMID 9422533.
Hughes AE, Bradley DT, Campbell M, Lechner J, Dash DP, Simpson DA, Willoughby CE (Nov 2011). "Mutation altering the miR-184 seed region causes familial keratoconus with cataract". American Journal of Human Genetics. 89 (5): 628–33. doi:10.1016/j.ajhg.2011.09.014. PMC 3213395. PMID 21996275.

External links[edit]

GeneReviews/NCBI/NIH/UW entry on Epidermolysis Bullosa with Pyloric Atresia
ITGB4+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
ITGB4 Info with links in the Cell Migration Gateway Archived 2014-12-11 at the Wayback Machine

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000132470 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020758 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: ITGB4 integrin, beta 4".

[pmid9500991-6] Aho S, Uitto J (Feb 1998). "Direct interaction between the intracellular domains of bullous pemphigoid antigen 2 (BP180) and beta 4 integrin, hemidesmosomal components of basal keratinocytes". Biochemical and Biophysical Research Communications. 243 (3): 694–9. doi:10.1006/bbrc.1998.8162. PMID 9500991.

[pmid9660880-7] Schaapveld RQ, Borradori L, Geerts D, van Leusden MR, Kuikman I, Nievers MG, Niessen CM, Steenbergen RD, Snijders PJ, Sonnenberg A (Jul 1998). "Hemidesmosome formation is initiated by the beta4 integrin subunit, requires complex formation of beta4 and HD1/plectin, and involves a direct interaction between beta4 and the bullous pemphigoid antigen 180". The Journal of Cell Biology. 142 (1): 271–84. doi:10.1083/jcb.142.1.271. PMC 2133016. PMID 9660880.

[pmid9374518-8] Biffo S, Sanvito F, Costa S, Preve L, Pignatelli R, Spinardi L, Marchisio PC (Nov 1997). "Isolation of a novel beta4 integrin-binding protein (p27(BBP)) highly expressed in epithelial cells". The Journal of Biological Chemistry. 272 (48): 30314–21. doi:10.1074/jbc.272.48.30314. PMID 9374518.

[pmid11375975-9] Favre B, Fontao L, Koster J, Shafaatian R, Jaunin F, Saurat JH, Sonnenberg A, Borradori L (Aug 2001). "The hemidesmosomal protein bullous pemphigoid antigen 1 and the integrin beta 4 subunit bind to ERBIN. Molecular cloning of multiple alternative splice variants of ERBIN and analysis of their tissue expression". The Journal of Biological Chemistry. 276 (35): 32427–36. doi:10.1074/jbc.M011005200. PMID 11375975.

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v t e Proteins: clusters of differentiation (see also list of human clusters of differentiation)
1–50	CD1 a-c 1A 1B 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50
51–100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 - CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100
101–150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150
151–200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200
201–250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218 (a b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 - CD248 CD249
251–300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299
301–350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD327 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350

Function[edit]

Interactions[edit]

See also[edit]

References[edit]

Further reading[edit]

External links[edit]