FBXO5

FBXO5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2M6N, 4UI9
Identifiers
Aliases	FBXO5, EMI1, FBX5, Fbxo31, F-box protein 5
External IDs	OMIM: 606013 MGI: 1914391 HomoloGene: 8135 GeneCards: FBXO5
Gene location (Human)
Chr.	Chromosome 6 (human)
End	152,983,579 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	5,755,600 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; secondary oocyte; ; bone marrow; ; bone marrow cells; ; spongy bone; ; lymph node; ; stromal cell of endometrium; ; appendix; ; rectum; ; monocyte;
	Top expressed in
	hand; ; superior cervical ganglion; ; maxillary prominence; ; primitive streak; ; abdominal wall; ; medial ganglionic eminence; ; thymus; ; secondary oocyte; ; morula; ; dermis;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	metal ion binding; protein binding; protein kinase binding; ubiquitin ligase inhibitor activity; anaphase-promoting complex binding;
Cellular component	cytoplasm; cytosol; spindle; nucleoplasm; cytoskeleton; nucleus; meiotic spindle;
Biological process	vesicle organization; regulation of meiotic nuclear division; microtubule polymerization; negative regulation of meiotic nuclear division; regulation of transcription involved in G1/S transition of mitotic cell cycle; cell division; spindle assembly; oocyte maturation; regulation of mitotic cell cycle; cell cycle; spindle assembly involved in female meiosis I; regulation of mitotic nuclear division; negative regulation of ubiquitin protein ligase activity; anaphase-promoting complex-dependent catabolic process; negative regulation of mitotic metaphase/anaphase transition; regulation of DNA replication; positive regulation of cell population proliferation; positive regulation of G2/M transition of mitotic cell cycle; negative regulation of DNA endoreduplication; positive regulation of osteoblast differentiation; negative regulation of ubiquitin-protein transferase activity; positive regulation of biomineral tissue development; positive regulation of mesenchymal stem cell migration; negative regulation of cellular senescence; negative regulation of response to DNA damage stimulus; protein ubiquitination; regulation of mitotic cell cycle phase transition;
	Sources:Amigo / QuickGO
Orthologs
	26271
	67141
	ENSG00000112029
	ENSMUSG00000019773
	Q9UKT4
	Q7TSG3
	NM_001142522; NM_012177
	NM_025995
	NP_001135994; NP_036309
	NP_080271
	Wikidata
View/Edit Human	View/Edit Mouse

F-box only protein 5 is a protein that in humans is encoded by the FBXO5 gene.^[5]^[6]^[7]

Function[edit]

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. This protein is similar to xenopus early mitotic inhibitor-1 (Emi1), which is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex.^[7] Moreover, Emi1 also assembles a CRL1 complex that targets RAD51 for ubiquitin-mediated degradation.^[8]

Disease[edit]

Gene and protein expression of FBXO5/Emi1 are increased in many human cancers and increased expression has been shown to cause chromosome instability and cancer.^[9]

Interactions[edit]

FBXO5 has been shown to interact with:

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000112029 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000019773 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, Pagano M (October 1999). "Identification of a family of human F-box proteins". Current Biology. 9 (20): 1177–9. Bibcode:1999CBio....9.1177C. doi:10.1016/S0960-9822(00)80020-2. PMID 10531035. S2CID 7467493.
^ Winston JT, Koepp DM, Zhu C, Elledge SJ, Harper JW (October 1999). "A family of mammalian F-box proteins". Current Biology. 9 (20): 1180–2. Bibcode:1999CBio....9.1180W. doi:10.1016/S0960-9822(00)80021-4. PMID 10531037. S2CID 14341845.
^ ^a ^b "Entrez Gene: FBXO5 F-box protein 5".
^ ^a ^b Marzio A, Puccini J, Kwon Y, Maverakis NK, Arbini A, Sung P, et al. (January 2019). "The F-Box Domain-Dependent Activity of EMI1 Regulates PARPi Sensitivity in Triple-Negative Breast Cancers". Molecular Cell. 73 (2): 224–237.e6. doi:10.1016/j.molcel.2018.11.003. PMC 6995265. PMID 30554948.
^ Vaidyanathan S, Cato K, Tang L, Pavey S, Haass NK, Gabrielli BG, et al. (October 2016). "In vivo overexpression of Emi1 promotes chromosome instability and tumorigenesis". Oncogene. 35 (41): 5446–5455. doi:10.1038/onc.2016.94. PMID 27065322. S2CID 13540659.
^ ^a ^b Hsu JY, Reimann JD, Sørensen CS, Lukas J, Jackson PK (May 2002). "E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC(Cdh1)". Nature Cell Biology. 4 (5): 358–66. doi:10.1038/ncb785. PMID 11988738. S2CID 25403043.
^ Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, Pagano M (October 1999). "Identification of a family of human F-box proteins". Current Biology. 9 (20): 1177–9. Bibcode:1999CBio....9.1177C. doi:10.1016/S0960-9822(00)80020-2. PMID 10531035. S2CID 7467493.

Further reading[edit]

Gubin AN, Njoroge JM, Bouffard GG, Miller JL (July 1999). "Gene expression in proliferating human erythroid cells". Genomics. 59 (2): 168–77. doi:10.1006/geno.1999.5855. PMID 10409428.
Chiaur DS, Murthy S, Cenciarelli C, Parks W, Loda M, Inghirami G, et al. (2000). "Five human genes encoding F-box proteins: chromosome mapping and analysis in human tumors". Cytogenetics and Cell Genetics. 88 (3–4): 255–8. doi:10.1159/000015532. PMID 10828603. S2CID 431704.
Reimann JD, Freed E, Hsu JY, Kramer ER, Peters JM, Jackson PK (June 2001). "Emi1 is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex". Cell. 105 (5): 645–55. doi:10.1016/S0092-8674(01)00361-0. PMID 11389834. S2CID 16366514.
Reimann JD, Jackson PK (April 2002). "Emi1 is required for cytostatic factor arrest in vertebrate eggs". Nature. 416 (6883): 850–4. Bibcode:2002Natur.416..850R. doi:10.1038/416850a. PMID 11976684. S2CID 4403891.
Hsu JY, Reimann JD, Sørensen CS, Lukas J, Jackson PK (May 2002). "E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC(Cdh1)". Nature Cell Biology. 4 (5): 358–66. doi:10.1038/ncb785. PMID 11988738. S2CID 25403043.
Li Z, Hu CY, Mo BQ, Xu JD, Zhao Y (April 2003). "[Effect of beta-carotene on gene expression of breast cancer cells]". AI Zheng = Aizheng = Chinese Journal of Cancer. 22 (4): 380–4. PMID 12703993.
Margottin-Goguet F, Hsu JY, Loktev A, Hsieh HM, Reimann JD, Jackson PK (June 2003). "Prophase destruction of Emi1 by the SCF(betaTrCP/Slimb) ubiquitin ligase activates the anaphase promoting complex to allow progression beyond prometaphase". Developmental Cell. 4 (6): 813–26. doi:10.1016/S1534-5807(03)00153-9. PMID 12791267.
Moshe Y, Boulaire J, Pagano M, Hershko A (May 2004). "Role of Polo-like kinase in the degradation of early mitotic inhibitor 1, a regulator of the anaphase promoting complex/cyclosome". Proceedings of the National Academy of Sciences of the United States of America. 101 (21): 7937–42. Bibcode:2004PNAS..101.7937M. doi:10.1073/pnas.0402442101. PMC 419535. PMID 15148369.
Hansen DV, Loktev AV, Ban KH, Jackson PK (December 2004). "Plk1 regulates activation of the anaphase promoting complex by phosphorylating and triggering SCFbetaTrCP-dependent destruction of the APC Inhibitor Emi1". Molecular Biology of the Cell. 15 (12): 5623–34. doi:10.1091/mbc.E04-07-0598. PMC 532041. PMID 15469984.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Eldridge AG, Loktev AV, Hansen DV, Verschuren EW, Reimann JD, Jackson PK (January 2006). "The evi5 oncogene regulates cyclin accumulation by stabilizing the anaphase-promoting complex inhibitor emi1". Cell. 124 (2): 367–80. doi:10.1016/j.cell.2005.10.038. PMID 16439210.
Lehman NL, Verschuren EW, Hsu JY, Cherry AM, Jackson PK (July 2006). "Overexpression of the anaphase promoting complex/cyclosome inhibitor Emi1 leads to tetraploidy and genomic instability of p53-deficient cells". Cell Cycle. 5 (14): 1569–73. doi:10.4161/cc.5.14.2925. PMID 16861914.
Miller JJ, Summers MK, Hansen DV, Nachury MV, Lehman NL, Loktev A, et al. (September 2006). "Emi1 stably binds and inhibits the anaphase-promoting complex/cyclosome as a pseudosubstrate inhibitor". Genes & Development. 20 (17): 2410–20. doi:10.1101/gad.1454006. PMC 1560415. PMID 16921029.
Marangos P, Verschuren EW, Chen R, Jackson PK, Carroll J (January 2007). "Prophase I arrest and progression to metaphase I in mouse oocytes are controlled by Emi1-dependent regulation of APC(Cdh1)". The Journal of Cell Biology. 176 (1): 65–75. doi:10.1083/jcb.200607070. PMC 2063628. PMID 17190794.

This article on a gene on human chromosome 6 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000112029 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000019773 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10531035-5] Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, Pagano M (October 1999). "Identification of a family of human F-box proteins". Current Biology. 9 (20): 1177–9. Bibcode:1999CBio....9.1177C. doi:10.1016/S0960-9822(00)80020-2. PMID 10531035. S2CID 7467493.

[pmid10531037-6] Winston JT, Koepp DM, Zhu C, Elledge SJ, Harper JW (October 1999). "A family of mammalian F-box proteins". Current Biology. 9 (20): 1180–2. Bibcode:1999CBio....9.1180W. doi:10.1016/S0960-9822(00)80021-4. PMID 10531037. S2CID 14341845.

[entrez-7] "Entrez Gene: FBXO5 F-box protein 5".

[Marzio_2019-8] Marzio A, Puccini J, Kwon Y, Maverakis NK, Arbini A, Sung P, et al. (January 2019). "The F-Box Domain-Dependent Activity of EMI1 Regulates PARPi Sensitivity in Triple-Negative Breast Cancers". Molecular Cell. 73 (2): 224–237.e6. doi:10.1016/j.molcel.2018.11.003. PMC 6995265. PMID 30554948.

[Vaidyanathan2016-9] Vaidyanathan S, Cato K, Tang L, Pavey S, Haass NK, Gabrielli BG, et al. (October 2016). "In vivo overexpression of Emi1 promotes chromosome instability and tumorigenesis". Oncogene. 35 (41): 5446–5455. doi:10.1038/onc.2016.94. PMID 27065322. S2CID 13540659.

[pmid11988738-10] Hsu JY, Reimann JD, Sørensen CS, Lukas J, Jackson PK (May 2002). "E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC(Cdh1)". Nature Cell Biology. 4 (5): 358–66. doi:10.1038/ncb785. PMID 11988738. S2CID 25403043.

[autogenerated1-11] Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, Pagano M (October 1999). "Identification of a family of human F-box proteins". Current Biology. 9 (20): 1177–9. Bibcode:1999CBio....9.1177C. doi:10.1016/S0960-9822(00)80020-2. PMID 10531035. S2CID 7467493.

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