BCL2L12

BCL2L12
Identifiers
Aliases	BCL2L12, BCL2 like 12
External IDs	OMIM: 610837 MGI: 1922986 HomoloGene: 12619 GeneCards: BCL2L12
Gene location (Human)
Chr.	Chromosome 19 (human)
End	49,673,916 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	44,648,136 bp
RNA expression pattern
	Top expressed in
	gastrocnemius muscle; ; oocyte; ; right lobe of liver; ; appendix; ; body of pancreas; ; gastric mucosa; ; bone marrow cells; ; spleen; ; left uterine tube; ; body of stomach;
	Top expressed in
	spermatocyte; ; hand; ; yolk sac; ; maxillary prominence; ; ascending aorta; ; foot; ; lip; ; seminiferous tubule; ; thymus; ; aortic valve;
	More reference expression data
	n/a
Gene ontology
Molecular function	p53 binding; protein binding;
Cellular component	membrane; nucleus;
Biological process	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; positive regulation of transcription by RNA polymerase II; inhibition of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of cellular senescence; apoptotic process; regulation of apoptotic process;
	Sources:Amigo / QuickGO
Orthologs
	83596
	75736
	ENSG00000126453
	ENSMUSG00000003190
	Q9HB09
	n/a
NM_001040668; NM_001282516; NM_001282517; NM_001282519; NM_001282520;
	NM_001282521; NM_138639; NM_001385706
	NM_029410
NP_001035758; NP_001269445; NP_001269446; NP_001269448; NP_001269449;
	NP_001269450; NP_619580
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Bcl-2-like protein 12 is a protein that in humans is encoded by the BCL2L12 gene.^[5]^[6]

The protein encoded by this gene belongs to the Bcl-2 protein family. Bcl-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein contains a Bcl-2 homology domain 2 (BH2). The function of this gene has not yet been determined. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.^[5]

Bcl2L12 expression is upregulated in most human glioblastomas. Expression of Bcl2L12 results in resistance to apoptosis. Bcl2L12 directly neutralizes caspase-7 (CASP7) and indirectly neutralizes caspase-3 (CASP3) by an indirect mechanism.^[7] Both caspase enzymes are known to play essential roles in the execution phase of apoptosis.^[8]

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000126453 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000003190 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: Bcl2L12 Bcl2-like 12 (proline rich)".
^ Scorilas A, Kyriakopoulou L, Yousef GM, Ashworth LK, Kwamie A, Diamandis EP (March 2001). "Molecular cloning, physical mapping, and expression analysis of a novel gene, BCL2L12, encoding a proline-rich protein with a highly conserved BH2 domain of the Bcl-2 family". Genomics. 72 (2): 217–21. doi:10.1006/geno.2000.6455. PMID 11401436.
^ Stegh AH, Kim H, Bachoo RM, Forloney KL, Zhang J, Schulze H, Park K, Hannon GJ, Yuan J, Louis DN, DePinho RA, Chin L (January 2007). "Bcl2L12 inhibits post-mitochondrial apoptosis signaling in glioblastoma". Genes Dev. 21 (1): 98–111. doi:10.1101/gad.1480007. PMC 1759904. PMID 17210792.
^ Wilson MR (August 1998). "Apoptosis: unmasking the executioner". Cell Death Differ. 5 (8): 646–52. doi:10.1038/sj.cdd.4400394. PMID 10200519.

External links[edit]

Human BCL2L12 genome location and BCL2L12 gene details page in the UCSC Genome Browser.

Further reading[edit]

Hammond PW, Alpin J, Rise CE, et al. (2001). "In vitro selection and characterization of Bcl-X(L)-binding proteins from a mix of tissue-specific mRNA display libraries". J. Biol. Chem. 276 (24): 20898–906. doi:10.1074/jbc.M011641200. PMID 11283018.
Scorilas A, Kyriakopoulou L, Yousef GM, et al. (2001). "Molecular cloning, physical mapping, and expression analysis of a novel gene, BCL2L12, encoding a proline-rich protein with a highly conserved BH2 domain of the Bcl-2 family". Genomics. 72 (2): 217–21. doi:10.1006/geno.2000.6455. PMID 11401436.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Talieri M, Diamandis EP, Katsaros N, et al. (2004). "Expression of BCL2L12, a new member of apoptosis-related genes, in breast tumors". Thromb. Haemost. 89 (6): 1081–8. doi:10.1055/s-0037-1613411. PMID 12783122. S2CID 44619207.
Hillman RT, Green RE, Brenner SE (2005). "An unappreciated role for RNA surveillance". Genome Biol. 5 (2): R8. doi:10.1186/gb-2004-5-2-r8. PMC 395752. PMID 14759258.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Mathioudaki K, Scorilas A, Papadokostopoulou A, et al. (2005). "Expression analysis of BCL2L12, a new member of apoptosis-related genes, in colon cancer". Biol. Chem. 385 (9): 779–83. doi:10.1515/BC.2004.101. PMID 15493871. S2CID 33174333.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000126453 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000003190 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Bcl2L12 Bcl2-like 12 (proline rich)".

[pmid11401436-6] Scorilas A, Kyriakopoulou L, Yousef GM, Ashworth LK, Kwamie A, Diamandis EP (March 2001). "Molecular cloning, physical mapping, and expression analysis of a novel gene, BCL2L12, encoding a proline-rich protein with a highly conserved BH2 domain of the Bcl-2 family". Genomics. 72 (2): 217–21. doi:10.1006/geno.2000.6455. PMID 11401436.

[pmid17210792-7] Stegh AH, Kim H, Bachoo RM, Forloney KL, Zhang J, Schulze H, Park K, Hannon GJ, Yuan J, Louis DN, DePinho RA, Chin L (January 2007). "Bcl2L12 inhibits post-mitochondrial apoptosis signaling in glioblastoma". Genes Dev. 21 (1): 98–111. doi:10.1101/gad.1480007. PMC 1759904. PMID 17210792.

[pmid10200519-8] Wilson MR (August 1998). "Apoptosis: unmasking the executioner". Cell Death Differ. 5 (8): 646–52. doi:10.1038/sj.cdd.4400394. PMID 10200519.

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